Document Detail

Functional association between proximal and distal gastric motility during fasting and duodenal nutrient stimulation in humans.
MedLine Citation:
PMID:  17640178     Owner:  NLM     Status:  MEDLINE    
A functional integration exists between proximal and distal gastric motor activity in dogs but has not been demonstrated in humans. To determine the relationship between proximal and distal gastric motor activity in humans. Concurrent proximal (barostat) and distal (antro-pyloro-duodenal (APD) manometry) gastric motility were recorded in 10 healthy volunteers (28 +/- 3 years) during (i) fasting and (ii) two 60-min duodenal infusions of Ensure((R)) (1 and 2 kcal min(-1)) in random order. Proximal and APD motor activity and the association between fundic and propagated antral waves (PAWs) were determined. During fasting, 32% of fundic waves (FWs) were followed by a PAW. In a dose-dependent fashion, duodenal nutrients (i) increased proximal gastric volume, (ii) reduced fundic and antral wave (total and propagated) activity, and (iii) increased pyloric contractions. The proportion of FWs followed by a distal PAW was similar between both infusions and did not differ from fasting. During nutrient infusion, nearly all PAWs were antegrade, propagated over a shorter distance and less likely to traverse the pylorus, compared with fasting. In humans, a functional association exists between proximal and distal gastric motility during fasting and duodenal nutrient stimulation. This may have a role in optimizing intra-gastric meal distribution.
N Q Nguyen; R J Fraser; L K Bryant; R H Holloway
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  19     ISSN:  1350-1925     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-20     Completed Date:  2007-09-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  638-45     Citation Subset:  IM    
Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
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MeSH Terms
Blood Glucose
Cardia / physiology
Dietary Sucrose
Duodenum / physiology
Eating / physiology*
Fasting / physiology*
Gastric Emptying / physiology*
Gastric Fundus / physiology
Muscle Contraction / physiology
Pyloric Antrum / physiology
Stomach / physiology*
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Sucrose; 109320-37-8/Ensure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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