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Functional assessment of tissue-engineered meniscal cartilage by magnetic resonance imaging and spectroscopy.
MedLine Citation:
PMID:  12625954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A perfusion bioreactor system was used to grow bioartificial meniscal cartilage tissue in vitro. Magnetic resonance imaging and magnetic resonance spectroscopy methods were used to characterize the flow and perfusion profiles and the growth, distribution, and bioenergetics of the fibrochondrocytes in the resulting constructs. These measurements were correlated with each other and with subsequent histologic analysis. The study has demonstrated that these noninvasive magnetic resonance methods will be useful for designing bioreactor operation strategies and cell scaffolds that lead to the production of tissue-engineered meniscal cartilage constructs with properties resembling those of the native tissue.
Authors:
André A Neves; Nick Medcalf; Kevin Brindle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tissue engineering     Volume:  9     ISSN:  1076-3279     ISO Abbreviation:  Tissue Eng.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-03-10     Completed Date:  2003-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9505538     Medline TA:  Tissue Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  51-62     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom. atrmdn2@mole.bio.cam.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Bioreactors
Cartilage / physiology*
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Tissue Engineering*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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