| Functional and anatomical diagnosis of coronary artery stenoses. | |
| | |
MedLine Citation:
|
PMID: 18262546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Functional/physiological evaluation of coronary artery stenoses may be more important than anatomical measurements of severity. Optimization of thresholds for stenosis intervention and treatment endpoints depend on coupling functional hemodynamic and anatomical data. We sought to develop a single prognostic parameter correlating stenosis-specific anatomy, pressure gradient, and velocities that could be measured during catheterization. MATERIALS AND METHODS: In vivo Experiments were performed in six swine (41 +/- 3 kg). The lumen area of the left anterior descending coronary artery was measured with intravascular ultrasound. An angioplasty balloon was inflated to create the desired intraluminal area obstructions. Fractional flow reserve (FFR), coronary flow reserve (CFR), and hyperemic-stenosis-resistance index were measured distal to the balloon at peak hyperemia with 10 mg intracoronary papaverine. A functional index:pressure drop coefficient (CDP) and a combined functional and anatomical index:lesion flow coefficient (LFC) were calculated from measured hyperemic pressure gradient, velocity, and percentage area stenosis. P < 0.05 was considered statistically significant. RESULTS: The CDP and LFC correlated linearly and significantly with FFR and CFR. The CDP (R(2) = 0.72, P < 0.0001) correlated better than LFC (R(2) = 0.19, P < 0.003) with hyperemic-stenosis-resistance index. When LFC was correlated simultaneously with FFR and CFR, R(2) improved to 0.82 (P < 0.0001). Inclusion of percentage area stenoses concurrently with FFR and CFR marginally improved the correlation with LFC. CONCLUSIONS: A dimensionless parameter combining measured pressure gradient, velocity, and area reduction data can optimally define the severity of coronary stenoses based on our preliminary results and could prove useful clinically. |
| | |
Authors:
|
Abhijit Sinha Roy; Martin R Back; Saeb F Khoury; Eric W Schneeberger; Lloyd H Back; Vijaya V Velury; Ronald W Millard; Rupak K Banerjee |
Related Documents
:
|
356056 - Coronary vasodilator activity of 13,14-dehydroprostacyclin methyl ester: comparison wit... 15820206 - Aging decreases vasoconstrictor responses of coronary resistance arterioles through end... 7270436 - Redistribution of myocardial blood flow distal to a dynamic coronary arterial stenosis ... 9532006 - Immunopathological mechanisms underlying the time-course of trichinella spiralis cardio... 6755116 - Studies in transtracheal ventilation catheters. 9271276 - Preventing gastroepiploic artery spasm: papaverine vs calcium channel blockade. |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-11-29 |
Journal Detail:
|
Title: The Journal of surgical research Volume: 150 ISSN: 1095-8673 ISO Abbreviation: J. Surg. Res. Publication Date: 2008 Nov |
Date Detail:
|
Created Date: 2008-10-20 Completed Date: 2008-11-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: United States |
Other Details:
|
Languages: eng Pagination: 24-33 Citation Subset: IM |
Affiliation:
|
Department of Mechanical Engineering, University of Cincinnati, Cincinnati, Ohio 45221-0072, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure* Coronary Circulation* Coronary Stenosis / diagnosis*, pathology, physiopathology Coronary Vessels / pathology Heart Catheterization Swine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The surface location of individual residues in a bacterial S-layer protein.
Next Document: Clinical significance of preoperative lymphoscintigraphy for sentinel lymph node biopsy in breast ca...