Document Detail


Functional analysis of neurovascular adaptations to exercise in the dentate gyrus of young adult mice associated with cognitive gain.
MedLine Citation:
PMID:  19132736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The discovery that aerobic exercise increases adult hippocampal neurogenesis and can enhance cognitive performance holds promise as a model for regenerative medicine. This study adds two new pieces of information to the rapidly growing field. First, we tested whether exercise increases vascular density in the granular layer of the dentate gyrus, whole hippocampus, and striatum in C57BL/6J mice known to display procognitive effects of exercise. Second, we determined the extent to which new neurons from exercise participate in the acute neuronal response to high levels of running in B6D2F1/J (F1 hybrid of C57BL/6J female by DBA/2J male). Mice were housed with or without a running wheel for 50 days (runner vs. sedentary). The first 10 days, they received daily injections of BrdU to label dividing cells. The last 10 days, mice were tested for performance on the Morris water maze and rotarod and then euthanized to measure neurogenesis, c-Fos induction from running and vascular density. In C57BL/6J, exercise increased neurogenesis, density of blood vessels in the dentate gyrus and striatum (but not whole hippocampus), and enhanced performance on the water maze and rotarod. In B6D2F1/J, exercise also increased hippocampal neurogenesis but not vascular density in the granular layer. Improvement on the water maze from exercise was marginal, and no gain was seen for rotarod, possibly because of a ceiling effect. Running increased the number of c-Fos positive neurons in the granular layer by fivefold, and level of running was strongly correlated with c-Fos within 90 min before euthanasia. In runners, approximately 3.3% (+/-0.008 S.E.) of BrdU-positive neurons in the middle of the granule layer displayed c-Fos when compared with 0.8% (+/-0.001) of BrdU-negative neurons. Results suggest that procognitive effects of exercise are associated with increased vascular density in the dentate gyrus and striatum in C57BL/6J mice, and that new neurons from exercise preferentially function in the neuronal response to running in B6D2F1/J.
Authors:
Peter J Clark; Weronika J Brzezinska; Emily K Puchalski; David A Krone; Justin S Rhodes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hippocampus     Volume:  19     ISSN:  1098-1063     ISO Abbreviation:  Hippocampus     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-01     Completed Date:  2009-12-14     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  9108167     Medline TA:  Hippocampus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  937-50     Citation Subset:  IM    
Copyright Information:
Copyright 2008 Wiley-Liss, Inc.
Affiliation:
Department of Psychology, The Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cognition / physiology*
Corpus Striatum / blood supply,  physiology
Dentate Gyrus / blood supply*,  physiology*
Female
Hippocampus / blood supply,  physiology
Male
Maze Learning / physiology
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Motor Activity / physiology
Neovascularization, Physiologic / physiology*
Neurogenesis / physiology
Neurons / physiology
Physical Conditioning, Animal / physiology*
Running / physiology*
Species Specificity
Time Factors
Grant Support
ID/Acronym/Agency:
R01 DA027487/DA/NIDA NIH HHS; R01 DA027487-01/DA/NIDA NIH HHS; R01 MH083807/MH/NIMH NIH HHS; R01 MH083807-01A1/MH/NIMH NIH HHS
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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