Document Detail

Functional alterations of murine peritoneal macrophages during pregnancy.
MedLine Citation:
PMID:  1319175     Owner:  NLM     Status:  MEDLINE    
We have studied some functional characteristics of murine peritoneal macrophages (MOp) related to hormonal changes produced during pregnancy. Maximal expression of Ia antigen and release of interleukin 1 (IL1) were observed during the first week of pregnancy (implantation), when the highest peak of estradiol was produced. Both Ia antigen expression and IL1 levels progressively decreased as gestation advanced. Inversely, MOp capability to phagocyte and reduce nitro blue tetrazolium (NBT) was diminished at the beginning of pregnancy but returned to normal values in the last week. Sexual steroid levels (estradiol and progesterone) were inversely related, and the release of prostaglandin E2 (PGE2) by MOp decreased when progesterone levels increased. Although PGE2 production had no evident relation with Ia antigen expression and IL1 activity during the first and second weeks of pregnancy, the increment in PGE2 values and percentages of NBT+ cells could indicate a different stage of macrophage activation. These results suggest a possible hormonal regulation of macrophage functionality.
R I Barañao; A Tenenbaum; M E Sales; L S Rumi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  27     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:    1992 Jan-Mar
Date Detail:
Created Date:  1992-07-30     Completed Date:  1992-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  82-6     Citation Subset:  IM    
Instituto de Biologia y Medicina Experimental (IBYME), Buenos Aires, Argentina.
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MeSH Terms
Dinoprostone / blood
Gonadal Steroid Hormones / blood
Histocompatibility Antigens Class II / analysis
Interleukin-1 / secretion
Macrophage Activation
Macrophages / physiology*
Mice, Inbred BALB C / immunology
Mice, Inbred C3H / immunology
Peritoneal Cavity / cytology
Pregnancy, Animal / blood,  immunology*
Reg. No./Substance:
0/Gonadal Steroid Hormones; 0/Histocompatibility Antigens Class II; 0/Interleukin-1; 363-24-6/Dinoprostone

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