| Functional activity of uremic erythroblast incubated in autologous and homologous plasma. | |
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MedLine Citation:
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PMID: 444684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The uptake of 3H-thymidine, 3H-uridine and 3H-leucine in the erythroid precursors of patients with chronic renal failure (CRF) was examined by radioautography. The pattern of incorporation of the radioactive precursors was similar to that observed in erythroblasts of control subjects, i.e., the uptake decreased with cell maturation. CRF erythroblasts incubated with normal, homologous plasma, showed significant increase in the uptake of the radioactive precursors, compared to the activity of these cells incubated in autologous plasms, the only exception being the incorporation of 3H-leucine in the proerythroblasts, in which the increase was not statistically significant. These results suggest that the impaired function of CRF erythroblasts related to DNA, RNA and protein synthesis is due not to a defective mechanism in the cells themselves, but most probably to the effect of factors present in uremic plasma, the nature of which remains to be detected. |
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Authors:
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M Mitelman; J Levi; M Djaldetti |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blut Volume: 38 ISSN: 0006-5242 ISO Abbreviation: Blut Publication Date: 1979 Jun |
Date Detail:
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Created Date: 1979-08-29 Completed Date: 1979-08-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0173401 Medline TA: Blut Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 467-71 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Proteins / biosynthesis DNA / biosynthesis Erythroblasts / metabolism* Erythrocytes / metabolism* Female Humans Leucine / metabolism Male Middle Aged RNA / biosynthesis Thymidine / metabolism Uremia / blood* Uridine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 50-89-5/Thymidine; 58-96-8/Uridine; 61-90-5/Leucine; 63231-63-0/RNA; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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