Document Detail

Functional abilities at age 4 years of children born before 29 weeks of gestation.
MedLine Citation:
PMID:  7688251     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To assess the rate of impairment and disability among babies born very preterm and to investigate the association between such impairment and gestational age at birth. DESIGN: Cohort study of a geographically defined population of babies. SETTING: Oxford Regional Health Authority. SUBJECTS: All babies born alive before 29 weeks of gestation to mothers resident in the region during 1984-6. MAIN OUTCOME MEASURES: Survival rates and rates of impairment and disability among survivors at the age of 4 years. RESULTS: Of the 342 babies, half (170) survived to be discharged home. Of the 164 survivors to age 4 years, 153 (93%) were assessed. A total of 35 (23%; 95% confidence interval 16% to 30%) were severely disabled and only 54 (35%; 28% to 43%) were unimpaired. The risk of impairment and disability increased with decreasing gestational age at birth (p < 0.003). CONCLUSIONS: With the increasing survival rate among babies born before 29 weeks of gestation, we need urgently to establish reliable ways of monitoring the proportion of survivors who have a disability.
A Johnson; P Townshend; P Yudkin; D Bull; A R Wilkinson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BMJ (Clinical research ed.)     Volume:  306     ISSN:  0959-8138     ISO Abbreviation:  BMJ     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-09-07     Completed Date:  1993-09-07     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8900488     Medline TA:  BMJ     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1715-8     Citation Subset:  AIM; IM    
National Perinatal Epidemiology Unit, Radcliffe Infirmary, Oxford.
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MeSH Terms
Child, Preschool
Cohort Studies
Developmental Disabilities / etiology,  physiopathology
Disabled Persons*
England / epidemiology
Gestational Age
Infant, Newborn
Infant, Premature*
Risk Factors
Comment In:
BMJ. 1993 Aug 21;307(6902):502   [PMID:  8400949 ]
BMJ. 1993 Aug 21;307(6902):502   [PMID:  8400948 ]

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