Document Detail

Functional Split between Parietal and Entorhinal Cortices in the Rat.
MedLine Citation:
PMID:  22365551     Owner:  NLM     Status:  In-Data-Review    
Posterior parietal cortex (PPC) and medial entorhinal cortex (MEC) are important elements of the neural circuit for space, but whether representations in these areas are controlled by the same factors is unknown. We recorded single units simultaneously in PPC and MEC of freely foraging rats and found that a subset of PPC cells are tuned to specific modes of movement irrespective of the animals' location or heading, whereas grid cells in MEC expressed static spatial maps. The behavioral correlates of PPC cells switched completely when the same animals ran in a spatially structured maze or when they ran similar stereotypic sequences in an open arena. Representations in PPC were similar in identical mazes in different rooms where grid cells completely realigned their firing fields. The data suggest that representations in PPC are determined by the organization of actions while cells in MEC are driven by spatial inputs.
Jonathan R Whitlock; Gerit Pfuhl; Nenitha Dagslott; May-Britt Moser; Edvard I Moser
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuron     Volume:  73     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  789-802     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Kavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, NO-7489 Trondheim, Norway.
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