| Functional redundancy of Langerhans cells and Langerin+ dermal dendritic cells in contact hypersensitivity. | |
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MedLine Citation:
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PMID: 20703247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relative roles of Langerhans cells (LC), dermal dendritic cells (DC), and, in particular, the recently discovered Langerin(+) dermal DC subset in the induction and control of contact hypersensitivity (CHS) responses remain controversial. Using an inducible mouse model, in which LC and other Langerin(+) DC can be depleted by injection of diphtheria toxin, we previously reported impaired transport of topically applied antigen to draining lymph nodes and reduced CHS in the absence of all Langerin(+) skin DC. In this study, we demonstrate that mice with a selective depletion of LC exhibit attenuated CHS only upon sensitization with a low hapten dose but not with a high hapten dose. In contrast, when painting a higher concentration of hapten onto the skin, which leads to increased antigen dissemination into the dermis, CHS is still diminished in mice lacking all Langerin(+) skin DC. Taken together, these data suggest that the magnitude of a CHS reaction depends on the number of skin DC, which have access to the hapten, rather than on the presence or absence of a particular skin DC population. LC and (Langerin(+)) dermal DC thus seem to have a redundant function in regulating CHS. |
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Authors:
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Madelon Noordegraaf; Vincent Flacher; Patrizia Stoitzner; Björn E Clausen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-12 |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 130 ISSN: 1523-1747 ISO Abbreviation: J. Invest. Dermatol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-11 Completed Date: 2010-12-17 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 2752-9 Citation Subset: IM |
Affiliation:
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Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Surface / genetics*, metabolism Dermatitis, Contact / immunology*, pathology* Dermis / immunology, pathology Diphtheria Toxin / toxicity Disease Models, Animal Epidermis / immunology, pathology Gene Knock-In Techniques Haptens / immunology Intercellular Signaling Peptides and Proteins / genetics, metabolism Langerhans Cells / immunology*, pathology* Lectins, C-Type / genetics*, metabolism Mannose-Binding Lectins / genetics*, metabolism Mice Mice, Inbred C57BL Mice, Mutant Strains Organ Culture Techniques Poisons / toxicity |
| Grant Support | |
ID/Acronym/Agency:
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P 21487-B13//Austrian Science Fund FWF |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Surface; 0/Cd207 protein, mouse; 0/Diphtheria Toxin; 0/Haptens; 0/Intercellular Signaling Peptides and Proteins; 0/Lectins, C-Type; 0/Mannose-Binding Lectins; 0/Poisons; 149176-25-0/heparin-binding EGF-like growth factor |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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