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Functional and Quality of Life Outcomes of Transoral Robotic Surgery for Carcinoma of Unknown Primary.
MedLine Citation:
PMID:  24706455     Owner:  NLM     Status:  Publisher    
Objective: To determine speech, eating, aesthetics, social disruption, and overall quality of life outcomes over a year period in patients who underwent transoral robotic surgery as part of carcinoma of unknown primary diagnosis and treatment. Study Design: Observational prospective study. Methods: Twenty-two patients who underwent transoral robotic surgery for the management of carcinoma of unknown primary were included. Patients prospectively completed the Head and Neck Cancer Inventory during pre-operative visit, and at 3 weeks, 3, 6, 12 months post-operative visits. Patients' demographic, pathological, and follow-up information were also collected. Results: The mean follow-up time was 19.8 months. There were overall declines in all quality of life scores during treatment period, which was followed by a continuous recovery. The scores immediately after transoral robotic surgery (3 weeks) were significantly higher than the scores after conclusion of adjuvant therapy (3 months) in multiple domains (P<0.05) and the 6-month scores in speech (P=0.02) and eating (P=0.008) domains. All scores, except for eating (P=0.01) returned to pre-treatment levels at 1 year. Patients with detected primaries displayed similar quality of life scores compared to patients with occult primaries. Human papilloma virus status and type of adjuvant treatment had no significant impact on quality of life Conclusion: Transoral robotic surgery is a promising minimally invasive procedure for the surgical management of carcinoma of unknown primary. Patients maintain high functional and quality of life status at 1 year after surgery.
Kasim Durmus; Hafiz S Patwa; Hamza N Gokozan; Cuneyt Kucur; Theodoros N Teknos; Amit Agrawal; Matthew O Old; Enver Ozer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-5
Journal Detail:
Title:  The Laryngoscope     Volume:  -     ISSN:  1531-4995     ISO Abbreviation:  Laryngoscope     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 The American Laryngological, Rhinological, and Otological Society, Inc.
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