Document Detail

Functional polymorphism of cyclooxygenase-2 gene (G-765C) in depressive patients.
MedLine Citation:
PMID:  20588070     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Depressive disorder (DD) is characterized by an inflammatory process and oxidative stress. Cyclooxygenase-2 (COX-2), the expression of which increases in depression, is an enzyme involved in inflammation and free radical processes. The aim of our study was to assess the correlation between single nucleotide polymorphism G-765C of the COX-2 gene and recurrent DD. METHODS: The study was carried out in a group of 181 patients treated for recurrent DD, and in 149 healthy subjects of the control group (CG). Polymerase chain reaction/restriction fragment length polymorphism was used for genotyping. RESULTS: A statistically significant difference in genotype distribution was observed as a result of the comparison between the CG and the patients with DD. We demonstrated that the presence of the -765G allele in the COX-2 gene increased 2.1-fold the risk of DD development, whereas the presence of a homozygote (G-765G) in the analyzed gene increased the risk of DD development 2.5-fold. CONCLUSION: According to the obtained results, it may be proposed with some caution that the presence of both the -765G allele and the G-765G genotype in the COX-2 gene may confer a susceptibility to an increased risk of recurrent DD in the Polish population.
Piotr Gałecki; Antoni Florkowski; Małgorzata Bieńkiewicz; Janusz Szemraj
Publication Detail:
Type:  Journal Article     Date:  2010-06-30
Journal Detail:
Title:  Neuropsychobiology     Volume:  62     ISSN:  1423-0224     ISO Abbreviation:  Neuropsychobiology     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7512895     Medline TA:  Neuropsychobiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  116-20     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Department of Adult Psychiatry, Medical University of Lodz, Lodz, Poland. galeckipiotr @
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MeSH Terms
Chi-Square Distribution
Cyclooxygenase 2 / genetics*
DNA Mutational Analysis / methods
Depressive Disorder / genetics*
Gene Frequency
Genetic Predisposition to Disease*
Polymorphism, Single Nucleotide / genetics*
Reg. No./Substance:
EC 2

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