Document Detail


A Functional Platform for Controlled Subcellular Distribution of Carbon Nanotubes.
MedLine Citation:
PMID:  21981659     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
As nanoparticles can cross different cellular barriers and access different tissues, control of their uptake and cellular fate presents a functional approach that will be broadly applicable to nanoscale technologies in cell biology. Here we show that the trafficking of single walled carbon nanotubes (SWCNTs) through various subcellular membranes of the plant cell is facilitated or inhibited by attaching a suitable functional tag and controlling medium components. This enables a unique control over the uptake and the subcellular distribution of SWCNTs and provides a key strategy to promote their cellular elimination to minimize toxicity. Our results also demonstrate that SWCNTs are involved in a carrier-mediated transport (CMT) inside cells; this is a phenomenon which scientists could use to obtain novel molecular insights into CMT, with the potential translation to advances in subcellular nanobiology.
Authors:
Maged F Serag; Noritada Kaji; Enrica Venturelli; Yukihiro Okamoto; Kazuyoshi Terasaka; Manabu Tokeshi; Hajime Mizukami; Kevin Braeckmans; Alberto Bianco; Yoshinobu Baba
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-7
Journal Detail:
Title:  ACS nano     Volume:  -     ISSN:  1936-086X     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101313589     Medline TA:  ACS Nano     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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