Document Detail


Functional Phenotyping of Mouse Models with ERG.
MedLine Citation:
PMID:  23150360     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In many situations it is important to be able to assess the degree of retinal function, e.g., for the characterization of mouse models with unknown retinal involvement, when studying degenerative processes, for the analysis of visual signal processing, and during the follow-up of therapeutic interventions. Full-field electroretinography (ERG), yielding a sum response of event-related transient electrical activity of the entire retina to light stimulation, is widely applied in human as well as experimental functional diagnostics. ERG examinations normally include initial dark-adapted (scotopic) measurements that enable rod-driven activity to be studied, followed by light-adapted (photopic) recordings to obtain information about cone system contributions. The results allow the correlation of acute or long-term disease-related changes or their alleviation by therapy with morphological data, in order to obtain a comprehensive understanding of the underlying processes and mechanisms.
Authors:
Naoyuki Tanimoto; Vithiyanjali Sothilingam; Mathias W Seeliger
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  935     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  69-78     Citation Subset:  -    
Affiliation:
Division of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany, naoyuki.tanimoto@med.uni-tuebingen.de.
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