Document Detail

Functional and phenotypical impairment of polymorphonuclear cells in atopic dermatitis: an additional cause for the known susceptibility to infections?.
MedLine Citation:
PMID:  22710427     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Atopic dermatitis (AD) patients present an high susceptibility to infections. The phagocytic activity of polymorphonuclear granulocytes (PMNs) is mediated by the interactions between Toll-like receptors (TLRs) and pathogen-associated molecular patterns.
OBJECTIVE: To investigate functional activity and phenotype of PMNs in AD patients.
METHODS: In vitro PMN phagocytosis and intracellular killing towards Klebsiella pneumoniae were evaluated in 24 AD patients; flow cytometry was applied to analyze PMN phenotype.
RESULTS: PMNs from AD patients displayed both reduced phagocytic activity and intracellular killing against K. pneumoniae than healthy subjects (HS). CD11b, CD66b, TLR2, TLR4 and TLR5 median fluorescence intensity (MFI) on PMN membrane were significantly higher in AD patients than in HS.
CONCLUSION: PMN functional impairment in AD patients could represent an additional cause of skin infections, coupled with other known defects in the innate immune system. The increased MFI of adhesion molecules and TLRs is rather a consequence of the increased skin barrier permeability to bacterial molecules capable of stimulating immunological reactions.
Maria Teresa Fierro; Giuliana Banche; Federica Marenco; Mauro Novelli; Valeria Allizond; Narcisa Mandras; Pierangela Murabito; Chiara Merlino; Pietro Quaglino; Maria Grazia Bernengo; Anna Maria Cuffini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-18
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  224     ISSN:  1421-9832     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-02     Completed Date:  2012-12-17     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  323-30     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
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MeSH Terms
Cohort Studies
Dermatitis, Atopic / immunology*,  microbiology
Disease Susceptibility
Flow Cytometry
Klebsiella Infections / immunology*,  microbiology
Klebsiella pneumoniae / physiology
Middle Aged
Neutrophils / physiology*
Phagocytes / immunology*
Phagocytosis / physiology
Toll-Like Receptors / metabolism
Young Adult
Reg. No./Substance:
0/Toll-Like Receptors

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