Document Detail

[Functional Network between Bone and Organs. Parathyroid hormone : its anabolic action on bone].
MedLine Citation:
PMID:  23354087     Owner:  NLM     Status:  In-Data-Review    
PTH actions on bone are exerted through multiple pathways from G-proteins coupled to a receptor PTH1R that is expressed on osteoblastic lineage cells. Physiological action of PTH may be through increased expression of RANKL, resulting in increased bone resorption and Ca( + + ) release from bone matrix by osteoclasts. Bone anabolic action of PTH by intermittent treatment is explained by ( I ) proliferation of osteogenic precursor cells, ( II ) differentiation of osteoblasts, ( III ) inhibition of apoptosis in osteoblastic cells, and ( IV ) inhibition of canonical Wnt inhibitor secretion from osteocytes. Two of these mechanisms ( II and III ) could be secondary to increased osteoclastogenesis after induction of RANKL in osteoblastic cells. Mechanisms involved in ( I ) might be controversial depending on cellular status including differentiation stages and cell density, and thus need to be clarified by further studies.
Yoichi Ezura; Masaki Noda
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Clinical calcium     Volume:  23     ISSN:  0917-5857     ISO Abbreviation:  Clin Calcium     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433326     Medline TA:  Clin Calcium     Country:  Japan    
Other Details:
Languages:  jpn     Pagination:  203-9     Citation Subset:  IM    
Department of Molecular Pharmacology, Tokyo Medical and Dental University, Medical Research Institute, Japan.
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