Document Detail

Functional magnetic resonance imaging analysis of food-related brain activity in patients with lipodystrophy undergoing leptin replacement therapy.
MedLine Citation:
PMID:  22872692     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Lipodystrophy is a disease characterized by a paucity of adipose tissue and low circulating concentrations of adipocyte-derived leptin. Leptin-replacement therapy improves eating and metabolic disorders in patients with lipodystrophy.
OBJECTIVE: The aim of the study was to clarify the pathogenic mechanism of eating disorders in lipodystrophic patients and the action mechanism of leptin on appetite regulation.
SUBJECTS AND INTERVENTIONS: We investigated food-related neural activity using functional magnetic resonance imaging in lipodystrophic patients with or without leptin replacement therapy and in healthy controls. We also measured the subjective feelings of appetite.
RESULTS: Although there was little difference in the enhancement of neural activity by food stimuli between patients and controls under fasting, postprandial suppression of neural activity was insufficient in many regions of interest including amygdala, insula, nucleus accumbens, caudate, putamen, and globus pallidus in patients when compared with controls. Leptin treatment effectively suppressed postprandial neural activity in many of these regions of interest, whereas it showed little effect under fasting in patients. Consistent with these results, postprandial formation of satiety feeling was insufficient in patients when compared with controls, which was effectively reinforced by leptin treatment.
CONCLUSIONS: This study demonstrated the insufficiency of postprandial suppression of food-related neural activity and formation of satiety feeling in lipodystrophic patients, which was effectively restored by leptin. The findings in this study emphasize the important pathological role of leptin in eating disorders in lipodystrophy and provide a clue to understanding the action mechanism of leptin in human, which may lead to development of novel strategies for prevention and treatment of obesity.
Daisuke Aotani; Ken Ebihara; Nobukatsu Sawamoto; Toru Kusakabe; Megumi Aizawa-Abe; Sachiko Kataoka; Takeru Sakai; Hitomi Iogawa; Chihiro Ebihara; Junji Fujikura; Kiminori Hosoda; Hidenao Fukuyama; Kazuwa Nakao
Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-07
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  97     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-08     Completed Date:  2012-12-18     Revised Date:  2013-10-10    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3663-71     Citation Subset:  AIM; IM    
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, and Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amygdala / physiology
Appetite / drug effects,  physiology
Cerebral Cortex / physiology
Corpus Striatum / physiology
Eating / drug effects,  physiology
Fasting / physiology
Feeding Behavior / drug effects,  physiology
Leptin / administration & dosage*,  deficiency,  physiology*
Lipodystrophy / drug therapy*,  physiopathology*
Magnetic Resonance Imaging
Nucleus Accumbens / physiology
Postprandial Period / physiology
Satiety Response / drug effects*,  physiology*
Young Adult
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Increased Cellular and Circulating Biomarkers of Oxidative Stress in Nascent Metabolic Syndrome.
Next Document:  Integration of balance and strength training into daily life activity to reduce rate of falls in old...