Document Detail

Functional MRI of visual cortex in sedated 18 month-old infants with or without periventricular leukomalacia.
MedLine Citation:
PMID:  11463181     Owner:  NLM     Status:  MEDLINE    
Functional MRI (fMRI) of the visual cortex was evaluated in 42 sedated 18-month-old infants (mean corrected age; 31 males, 11 females) with or without periventricular leukomalacia (PVL). Data from 14 infants could not be evaluated because of movement artefacts. Ten of the remaining 28 infants showed no significant fMRI response upon visual stimulation. In 18 infants, a significant signal change upon stimulation was found in the visual cortex: in 17 a signal decrease and in one a signal increase. Functional changes were located mainly in the anterior part of the visual cortex. Seven of the 28 infants had normal MRI and 21 showed variable occipital PVL. An fMRI response was equally frequent in infants without PVL (4 of 7 infants) and with PVL (14 of 21 infants). In conclusion, fMRI was shown to be feasible in sedated infants. No correlation was found between functional activation and the presence or absence of occipital PVL. Type of fMRI response (signal decrease) and localization (anterior part of the visual cortex) are different from those seen in adults, probably reflecting a combination of sedation effects and immaturity of the visual system. At present, fMRI is a highly promising research tool; its clinical relevance still has to be established.
Sie LTL; S A Rombouts; I J Valk; A A Hart; P Scheltens; M S van der Knaap
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  43     ISSN:  0012-1622     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-20     Completed Date:  2001-08-02     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  486-90     Citation Subset:  IM    
Department of Child Neurology, University Hospital, Vrije Universiteit, Amsterdam, The Netherlands.
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MeSH Terms
Case-Control Studies
Hypnotics and Sedatives / administration & dosage
Infant, Newborn
Leukomalacia, Periventricular / pathology*
Magnetic Resonance Imaging / methods*
Photic Stimulation
Visual Cortex / pathology*,  physiology*
Reg. No./Substance:
0/Hypnotics and Sedatives

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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