Document Detail

Functional MRI is a valid noninvasive alternative to Wada testing.
MedLine Citation:
PMID:  20850386     Owner:  NLM     Status:  MEDLINE    
Partial removal of the anterior temporal lobe (ATL) is a highly effective surgical treatment for intractable temporal lobe epilepsy, yet roughly half of patients who undergo left ATL resection show a decline in language or verbal memory function postoperatively. Two recent studies demonstrate that preoperative fMRI can predict postoperative naming and verbal memory changes in such patients. Most importantly, fMRI significantly improves the accuracy of prediction relative to other noninvasive measures used alone. Addition of language and memory lateralization data from the intracarotid amobarbital (Wada) test did not improve prediction accuracy in these studies. Thus, fMRI provides patients and practitioners with a safe, noninvasive, and well-validated tool for making better-informed decisions regarding elective surgery based on a quantitative assessment of cognitive risk.
Jeffrey R Binder
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-09-17
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  20     ISSN:  1525-5069     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-21     Completed Date:  2011-06-13     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  214-22     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
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MeSH Terms
Brain / blood supply*,  physiopathology
Epilepsy, Temporal Lobe / physiopathology*,  surgery*
Functional Laterality
Image Processing, Computer-Assisted / methods
Magnetic Resonance Imaging / methods*
Memory / physiology*
Oxygen / blood
Predictive Value of Tests
Verbal Learning / physiology*
Grant Support
M01 RR000058-390486/RR/NCRR NIH HHS; M01 RR000058-39S20486/RR/NCRR NIH HHS; M01 RR000058-430486/RR/NCRR NIH HHS; M01 RR000058-440486/RR/NCRR NIH HHS; M01 RR000058-455082/RR/NCRR NIH HHS; M01 RR00058/RR/NCRR NIH HHS; R01 NS035929-03/NS/NINDS NIH HHS; R01 NS035929-04/NS/NINDS NIH HHS; R01 NS035929-05/NS/NINDS NIH HHS; R01 NS035929-07/NS/NINDS NIH HHS; R01 NS035929-08/NS/NINDS NIH HHS; R01 NS035929-09/NS/NINDS NIH HHS; R01 NS35929/NS/NINDS NIH HHS
Reg. No./Substance:

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