| Functional MRI is a valid noninvasive alternative to Wada testing. | |
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MedLine Citation:
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PMID: 20850386 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Partial removal of the anterior temporal lobe (ATL) is a highly effective surgical treatment for intractable temporal lobe epilepsy, yet roughly half of patients who undergo left ATL resection show a decline in language or verbal memory function postoperatively. Two recent studies demonstrate that preoperative fMRI can predict postoperative naming and verbal memory changes in such patients. Most importantly, fMRI significantly improves the accuracy of prediction relative to other noninvasive measures used alone. Addition of language and memory lateralization data from the intracarotid amobarbital (Wada) test did not improve prediction accuracy in these studies. Thus, fMRI provides patients and practitioners with a safe, noninvasive, and well-validated tool for making better-informed decisions regarding elective surgery based on a quantitative assessment of cognitive risk. |
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Authors:
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Jeffrey R Binder |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-09-17 |
Journal Detail:
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Title: Epilepsy & behavior : E&B Volume: 20 ISSN: 1525-5069 ISO Abbreviation: Epilepsy Behav Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-21 Completed Date: 2011-06-13 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 100892858 Medline TA: Epilepsy Behav Country: United States |
Other Details:
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Languages: eng Pagination: 214-22 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. jbinder@mcw.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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blood supply*,
physiopathology Epilepsy, Temporal Lobe / physiopathology*, surgery* Functional Laterality Humans Image Processing, Computer-Assisted / methods Magnetic Resonance Imaging / methods* Memory / physiology* Oxygen / blood Predictive Value of Tests Verbal Learning / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR000058-390486/RR/NCRR NIH HHS; M01 RR000058-39S20486/RR/NCRR NIH HHS; M01 RR000058-430486/RR/NCRR NIH HHS; M01 RR000058-440486/RR/NCRR NIH HHS; M01 RR000058-455082/RR/NCRR NIH HHS; M01 RR00058/RR/NCRR NIH HHS; R01 NS035929-03/NS/NINDS NIH HHS; R01 NS035929-04/NS/NINDS NIH HHS; R01 NS035929-05/NS/NINDS NIH HHS; R01 NS035929-07/NS/NINDS NIH HHS; R01 NS035929-08/NS/NINDS NIH HHS; R01 NS035929-09/NS/NINDS NIH HHS; R01 NS35929/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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