Document Detail

Functional MRI and response inhibition in children exposed to cocaine in utero. Preliminary findings.
MedLine Citation:
PMID:  19372696     Owner:  NLM     Status:  MEDLINE    
This study investigated the potential long-term effects of cocaine exposure on brain functioning using fMRI in school-aged children. The sample included 12 children with prenatal cocaine exposure and 12 non-exposed children (8-9 years old). Groups did not differ on IQ, socioeconomic status, or perinatal risk factors. A response inhibition task was administered during an fMRI scan using a 1.5-T MRI system. Task performance did not differentiate groups, but groups were differentiated by patterns of task-related brain activity. Cocaine-exposed children showed greater activation in the right inferior frontal cortex and caudate during response inhibition, whereas non-exposed children showed greater activations in temporal and occipital regions. These preliminary findings suggest that prenatal cocaine may affect the development of brain systems involved in the regulation of attention and response inhibition.
Stephen J Sheinkopf; Barry M Lester; Jerome N Sanes; James C Eliassen; Emmette R Hutchison; Ronald Seifer; Linda L Lagasse; Sarah Durston; B J Casey
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Publication Detail:
Type:  Journal Article     Date:  2009-04-17
Journal Detail:
Title:  Developmental neuroscience     Volume:  31     ISSN:  1421-9859     ISO Abbreviation:  Dev. Neurosci.     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-17     Completed Date:  2009-06-16     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  7809375     Medline TA:  Dev Neurosci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  159-66     Citation Subset:  IM    
Copyright Information:
2009 S. Karger AG, Basel.
Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI 02905, USA.
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MeSH Terms
Behavior / drug effects
Cocaine / adverse effects*
Cocaine-Related Disorders / complications*
Cognition / drug effects
Data Interpretation, Statistical
Functional Laterality / drug effects
Gyrus Cinguli / pathology
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Prefrontal Cortex / pathology
Prenatal Exposure Delayed Effects / pathology*,  psychology*
Psychomotor Performance / drug effects
Reg. No./Substance:

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