Document Detail


Functional MRI and outcome in traumatic coma.
MedLine Citation:
PMID:  23881623     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Advances in task-based functional MRI (fMRI), resting-state fMRI (rs-fMRI), and arterial spin labeling (ASL) perfusion MRI have occurred at a rapid pace in recent years. These techniques for measuring brain function have great potential to improve the accuracy of prognostication for civilian and military patients with traumatic coma. In addition, fMRI, rs-fMRI, and ASL perfusion MRI have provided novel insights into the pathophysiology of traumatic disorders of consciousness, as well as the mechanisms of recovery from coma. However, functional neuroimaging techniques have yet to achieve widespread clinical use as prognostic tests for patients with traumatic coma. Rather, a broad spectrum of methodological hurdles currently limits the feasibility of clinical implementation. In this review, we discuss the basic principles of fMRI, rs-fMRI, and ASL perfusion MRI and their potential applications as prognostic tools for patients with traumatic coma. We also discuss future strategies for overcoming the current barriers to clinical implementation.
Authors:
Brian L Edlow; Joseph T Giacino; Ona Wu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Current neurology and neuroscience reports     Volume:  13     ISSN:  1534-6293     ISO Abbreviation:  Curr Neurol Neurosci Rep     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-07-24     Completed Date:  2014-03-27     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  100931790     Medline TA:  Curr Neurol Neurosci Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  375     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / pathology,  physiopathology*
Coma, Post-Head Injury / diagnosis,  physiopathology*
Humans
Magnetic Resonance Imaging* / methods
Perfusion / methods
Prognosis
Spin Labels
Grant Support
ID/Acronym/Agency:
R25 NS065743/NS/NINDS NIH HHS; R25NS065743/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Spin Labels
Comments/Corrections

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