| Functional MRI of liver using BOLD MRI: effect of glucose. | |
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MedLine Citation:
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PMID: 20882631 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To demonstrate feasibility of functional MRI of liver using glucose as a stimulus to monitor metabolic changes using blood oxygenation level dependent (BOLD) contrast. We hypothesized that during hyperglycemia, liver stores the glucose and consequently there is a reduction in oxygen consumption, which can be detected using BOLD MRI. MATERIALS AND METHODS: In four mini pigs, measurements were made before and after 54 g of glucose administered intravenously. In six healthy young human subjects, measurements were made before and after oral ingestion of 75 g of glucose. T(2)* weighted images of the liver were obtained on a Siemens 3 Tesla Verio MRI scanner using multiple gradient recalled echo (mGRE) sequence. RESULTS: A statistically significant decrease (P < 0.05) in R2* (1/T(2)*) was observed postglucose both in swine (110.41 ± 14.1 s(-1) to 72.22 ± 5.7 s(-1)) and human (55.84 ±3.8 s(-1) to 50.6 ±0.5 s(-1)), suggesting improved liver oxygenation during hyperglycemia. CONCLUSION: Our preliminary data presented here demonstrate the feasibility of obtaining functional liver images that illustrate the changes in oxygen consumption. Further studies are necessary to fully validate the technique. J. Magn. Reson. Imaging 2010;32:988-991. © 2010 Wiley-Liss, Inc. |
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Authors:
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Muhammad Haque; Ioannis Koktzoglou; Wei Li; Joann Carbray; Pottumarthi Prasad |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 32 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-30 Completed Date: 2011-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 988-91 Citation Subset: IM |
Affiliation:
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Department of Radiology, NorthShore University HealthSystem, Evanston, Illinois, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Blood Flow Velocity Female Glucose / metabolism*, pharmacology Humans Hyperglycemia Liver / pathology* Magnetic Resonance Imaging / methods* Male Oxygen Consumption Splanchnic Circulation Swine Swine, Miniature |
| Chemical | |
Reg. No./Substance:
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50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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