| Functional MRI BOLD signal coincides with electrical activity in the rat whisker barrels. | |
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MedLine Citation:
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PMID: 9402186 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Functional MRI (fMRI) provides a noninvasive method for mapping brain functional activity based on blood oxygenation level dependent (BOLD) image contrast that is primarily due to localized increases in perfusion. Recently, Malonek and Grinvald (Science 272:551-554, 1996) suggested that during sustained functional activation, the increases in perfusion were spread over a much larger area than the localized electrical activity. In this study, it is demonstrated that the spatial distribution of the BOLD fMRI signal during sustained stimulation of rat whiskers has the same spatial pattern and dimension as that of neuronal electrical activity in the rat whisker barrels. |
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Authors:
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X Yang; F Hyder; R G Shulman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 38 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-01-28 Completed Date: 1998-01-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 874-7 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Yale University, New Haven, Connecticut 06520-8043, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Electrophysiology Hair / physiology* Magnetic Resonance Imaging* Male Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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2-R01-DK 27121/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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