Document Detail


Functional MR imaging in patients with carotid artery stenosis before and after revascularization.
MedLine Citation:
PMID:  20801766     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Significant extracranial stenosis of the ICA is a known risk factor for future stroke and it has been shown that revascularization reduces the risk of future stroke. We applied BOLD fMRI in patients with carotid artery stenosis before and after CEA. Our purpose was to determine whether fMRI is able to demonstrate impaired CVR and to identify patient parameters that are associated with postoperative changes of cerebral hemodynamics.
MATERIALS AND METHODS: Nineteen consecutive patients with symptomatic (n = 13) and asymptomatic (n = 6) stenosis of the ICA were prospectively recruited (male/female ratio = 16:3; age, 69 ± 8,1 years). fMRI using a simple bilateral motor task was performed immediately before and after CEA.
RESULTS: Mean BOLD MSC was significantly increased postoperatively (MSC, 0.13 ± 0.66; P = 0.0002). Patients with a stenosis of <80% demonstrated an increase in MSC (MSC, 0.32 ± 0.59; P ≤ .0001). Patients with previous ischemic stroke showed a larger MSC than patients with TIAs (stroke: MSC, 0.55 ± 0.65; P ≤ .0001; TIA: MSC, 0.05 ± 0.26; P = 0.054). Patients older than 70 years had a significantly larger MSC following surgery (≤70 years: MSC, -0.01 ± 0.39; P = .429; >70 years: MSC, 0.29 ± 0.48; P ≤ .0001).
CONCLUSIONS: BOLD fMRI can demonstrate changes in cerebral hemodynamics before and after CEA, indicative of an ameliorated CVR. This response is dependent on the age of the patient, the degree of preoperative stenosis, and the patient's symptoms.
Authors:
M Schaaf; G Mommertz; A Ludolph; S Geibprasert; G Mühlenbruch; M Das; T Krings
Related Documents :
3815006 - Neurological morbidity of arch and carotid arteriography in cerebrovascular disease. th...
19199456 - The role of indirect extracranial-intracranial bypass in the treatment of symptomatic i...
10194586 - Prevention of vaginal stenosis in patients following vaginal brachytherapy.
19998256 - Association of plaque echostructure and cardiovascular risk factors with symptomatic ca...
21158216 - Adolescent acromegaly: clinical parameters and treatment outcome.
7221766 - Leiomyoma of the ovary. a report of 3 cases.
Publication Detail:
Type:  Journal Article     Date:  2010-08-26
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  31     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1791-8     Citation Subset:  IM    
Affiliation:
Departments of Neuroradiology, University Hospital Aachen, Aachen University, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  CT-guided cervical selective nerve root block with a dorsal approach.
Next Document:  Bringing forward reperfusion with oxygenated blood perfusion beyond arterial occlusion during endova...