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Functional Increase of Brain Histaminergic Signaling in Huntington's Disease.
MedLine Citation:
PMID:  21106039     Owner:  NLM     Status:  In-Data-Review    
To evaluate whether central histaminergic signaling in Huntington's disease (HD) patients is affected, we assessed mRNA levels of histidine decarboxylase (HDC), volume of and neuron number in the hypothalamic tuberomamillary nucleus (TMN) (HD n = 8, controls n = 8). In addition, we assessed histamine N-methyltransferase (HMT) and histamine receptor (H(1) R, H(2) R and H(3) R) mRNA levels in the inferior frontal gyrus (IFG) (n = 9 and 9) and caudate nucleus (CN) (n = 6 and 6) by real-time polymerase chain reaction. In HD patients, TMN volume and neuronal number was unaltered (P = 0.72, P = 0.25). The levels of HDC mRNA (P = 0.046), IFG HMT (P < 0.001), H(1) R (P < 0.001) and H(3) R mRNA levels (P = 0.011) were increased, while CN H(2) R and H(3) R mRNA levels were decreased (P = 0.041, P = 0.009). In HD patients, we observed a positive correlation between IFG H(3) R mRNA levels and CAG repeat length (P = 0.024) and negative correlations between age at onset of disease and IFG HMT (P = 0.015) and H(1) R (P = 0.021) mRNA levels. These findings indicate a functional increase in brain histaminergic signaling in HD, and provide a rationale for the use of histamine receptor antagonists.
Daniel J van Wamelen; Ling Shan; N Ahmad Aziz; Jasper J Anink; Ai-Min Bao; Raymund A C Roos; Dick F Swaab
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Publication Detail:
Type:  Journal Article     Date:  2010-12-27
Journal Detail:
Title:  Brain pathology (Zurich, Switzerland)     Volume:  21     ISSN:  1750-3639     ISO Abbreviation:  Brain Pathol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9216781     Medline TA:  Brain Pathol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  419-27     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Brain Pathology © 2010 International Society of Neuropathology.
Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Science, Amsterdam ZO. Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands. Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, China.
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