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Functional Impairment in the Diagnosis of Mild Cognitive Impairment.
MedLine Citation:
PMID:  21285856     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The criterion on functional activity in the revised diagnostic criteria for mild cognitive impairment (MCI) seems to be conceptually and operationally problematic.We investigated the predictive validity for dementia of this criterion in 140 patients with MCI who participated in the baseline study of the Korean Longitudinal Study on Health and Aging and completed 18-month follow-up evaluation (mean duration of follow-up, 1.57±0.24 y). Annual conversion rates to dementia were compared between the patients who fulfilled the criterion on functional activity and those who did not. Annual conversion rates to dementia of the patients who fulfilled the criterion on functional activity was 4.76%, whereas that of the patients with MCI who did not was 33.07%, indicating that the criterion on functional activity was a significant negative predictor of dementia (odds ratio=0.12). Re-revision of the criterion on functional activity may be warranted to solve its conceptual and operational ambiguities.
Authors:
Ji Won Han; Seok Bum Lee; Tae Hui Kim; Joon Hyuk Park; Jung Jae Lee; Yoon Seok Huh; Eun Ae Choi; Jin Yeong Choe; Yeon Ja Do; Dong Young Lee; Ki Woong Kim
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-29
Journal Detail:
Title:  Alzheimer disease and associated disorders     Volume:  -     ISSN:  1546-4156     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-2-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8704771     Medline TA:  Alzheimer Dis Assoc Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
*Department of Neuropsychiatry, Seoul National University Bundang Hospital, Gyeonggido †Department of Psychiatry, Dankook University Hospital, Chungcheongnamdo ‡Department of Neuropsychiatry, Jeju National University Hospital, Jejudo §Department of Psychiatry, Kyungbook National University Hospital, Daegu ∥Department of Psychiatry, Yesarang Hospital, Chungcheongbukdo ¶Department of Psychiatry, Seoul National University College of Medicine ♯Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.
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