Document Detail

Functional Dyspepsia: Impaired Fundic Accommodation.
MedLine Citation:
PMID:  11096589     Owner:  NLM     Status:  Publisher    
Functional dyspepsia is a heterogeneous disorder in which distinct pathophysiological abnormalities are present in subgroups of patients. Accommodation of the proximal stomach to a meal is impaired in 40% of patients with functional dyspepsia. This is associated with symptoms of early satiety and weight loss. The presence of early satiety as a relevant or severe symptom is a good predictor of impaired accommodation. Gastric barostat or proximal gastric ultrasound may confirm the presence of impaired accommodation after a meal. Sophisticated analysis of scintigraphic gastric emptying images or a simple caloric drinking test are under investigation in the diagnosis of impaired accommodation. It seems logical to have patients eat more frequent, smaller sized meals. Cisapride is the only well-evaluated form of pharmacological treatment for this condition, and has been withdrawn from the US market (see Important Note under Treatment, below). Small or preliminary studies suggest some benefit from buspirone or selective serotonin reuptake inhibitors (SSRIs).
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Publication Detail:
Journal Detail:
Title:  Current treatment options in gastroenterology     Volume:  3     ISSN:  1534-309X     ISO Abbreviation:  Curr Treat Options Gastroenterol     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815941     Medline TA:  Curr Treat Options Gastroenterol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  287-294     Citation Subset:  -    
Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Herestraat 49, B-3000 Leuven, Belgium. Jan.Tack@med.kuleuven.AC.BE
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