| Functional development of the T cell receptor for antigen. | |
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MedLine Citation:
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PMID: 20800817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For over three decades now, the T cell receptor (TCR) for antigen has not ceased to challenge the imaginations of cellular and molecular immunologists alike. T cell antigen recognition transcends every aspect of adaptive immunity: it shapes the T cell repertoire in the thymus and directs T cell-mediated effector functions in the periphery, where it is also central to the induction of peripheral tolerance. Yet, despite its central position, there remain many questions unresolved: how can one TCR be specific for one particular peptide-major histocompatibility complex (pMHC) ligand while also binding other pMHC ligands with an immunologically relevant affinity? And how can a T cell's extreme specificity (alterations of single methyl groups in their ligand can abrogate a response) and sensitivity (single agonist ligands on a cell surface are sufficient to trigger a measurable response) emerge from TCR-ligand interactions that are so low in affinity? Solving these questions is intimately tied to a fundamental understanding of molecular recognition dynamics within the many different contexts of various T cell-antigen presenting cell (APC) contacts: from the thymic APCs that shape the TCR repertoire and guide functional differentiation of developing T cells to the peripheral APCs that support homeostasis and provoke antigen responses in naïve, effector, memory, and regulatory T cells. Here, we discuss our recent findings relating to T cell antigen recognition and how this leads to the thymic development of foreign-antigen-responsive alphabetaT cells. |
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Authors:
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Peter J R Ebert; Qi-Jing Li; Johannes B Huppa; Mark M Davis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Progress in molecular biology and translational science Volume: 92 ISSN: 1877-1173 ISO Abbreviation: Prog Mol Biol Transl Sci Publication Date: 2010 |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-10-19 Revised Date: 2011-06-15 |
Medline Journal Info:
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Nlm Unique ID: 101498165 Medline TA: Prog Mol Biol Transl Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 65-100 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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The Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Antigen-Presenting Cells / immunology* Humans Molecular Sequence Data Peptide Fragments / immunology* Receptors, Antigen, T-Cell / immunology* Sequence Homology, Amino Acid T-Lymphocytes / immunology* Thymus Gland / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 0/Receptors, Antigen, T-Cell |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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