Document Detail


Functional capacity of neutrophils from class III obese patients.
MedLine Citation:
PMID:  22158006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Class III obesity is associated with chronic inflammation and a variety of changes in immune function. Yet surprisingly little was known about the status of neutrophils that represent the first line of immune defense. The aim of this study was to assess key functions of neutrophils from class III obese patients, namely phagocytosis, superoxide production, chemotaxis, and response to endotoxin challenge, and compare their responses with lean controls. Thirty obese patients (BMI 48.8 ± 6.6 kg/m(2)) with comorbidities such as diabetes, hyperlipidemia, high blood pressure, etc. and nine lean (BMI between 20 and 25) subjects were enrolled in the study. Neutrophils from class III obese patients phagocytosed Escherichia coli (E. coli) at similar rates and with adequate numbers of bacteria taken up per cell compared with cells from lean subjects. Neutrophil production of superoxide, which is key to rapid killing of pathogens, showed modest diminution in the class III obese, which increased among patients with BMI >50. Chemotactic activity of neutrophils from class III obese patients was not altered. However, neutrophils from obese subjects showed an increased response to low-dose endotoxin, with concomitant reduced apoptosis and extension of their half-life compared with lean subjects, which suggests possible hyperresponsiveness of these neutrophils. Overall, neutrophil activity was not significantly altered by age, gender, diabetic status, or hyperlipidemia. Collectively, these results suggest that class III obese patients, even with comorbidities, have normal or nearly normal phagocytic, chemotactic, and superoxide generating capacity.
Authors:
Mark D Trottier; Afia Naaz; Kathy Kacynski; Panduranga R Yenumula; Pamela J Fraker
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-12-08
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  20     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-26     Completed Date:  2012-07-26     Revised Date:  2012-08-13    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1057-65     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Mass Index
Diabetes Mellitus / metabolism
Female
Gastric Bypass
Half-Life
Humans
Hyperlipidemias / metabolism
Lipopolysaccharides
Male
Middle Aged
Neutrophils / immunology*
Obesity, Morbid / complications,  immunology*,  surgery
Phagocytosis / immunology*
Severity of Illness Index
Superoxides / immunology,  metabolism*
Chemical
Reg. No./Substance:
0/Lipopolysaccharides; 11062-77-4/Superoxides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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