Document Detail


The functional architecture of the infant brain as revealed by resting-state FMRI.
MedLine Citation:
PMID:  20421249     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The functional network topology of the adult human brain has recently begun to be noninvasively mapped using resting-state functional connectivity magnetic resonance imaging and described using mathematical tools originating from graph theory. Previous studies have revealed the existence of disproportionally connected brain regions, so called cortical hubs, which act as information convergence zones and supposedly capture key aspects of how the brain's architecture supports human behavior and how it is affected by disease. In this study, we present results showing that cortical hubs and their associated cortical networks are largely confined to primary sensory and motor brain regions in the infant brain. Our findings in infants stand in stark contrast to the situation found in adults where the majority of cortical hubs and hub-related networks are located in heteromodal association cortex. Our findings suggest that the functional network architecture in infants is linked to support tasks that are of a perception-action nature.
Authors:
Peter Fransson; Ulrika Aden; Mats Blennow; Hugo Lagercrantz
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Publication Detail:
Type:  Journal Article     Date:  2010-04-26
Journal Detail:
Title:  Cerebral cortex (New York, N.Y. : 1991)     Volume:  21     ISSN:  1460-2199     ISO Abbreviation:  Cereb. Cortex     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9110718     Medline TA:  Cereb Cortex     Country:  United States    
Other Details:
Languages:  eng     Pagination:  145-54     Citation Subset:  IM    
Affiliation:
Department of Clinical Neuroscience, Karolinska Institute, SE-171 76 Stockholm, Sweden.
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