Document Detail

Function of vitamin A in normal and synchronized seminiferous tubules.
MedLine Citation:
PMID:  2672955     Owner:  NLM     Status:  MEDLINE    
Vitamin A is clearly an important factor in spermatogenesis. Some of the new data on metabolism of retinoids in the testis has contributed to our understanding of the mechanism(s) involved in the action of vitamin A. It is probable that the requirement of the testis of vitamin A deficient rats for retinol but not retinoic acid involves access of the retinoids to various testicular compartments. Retinol may be required by germinal cells because of a requirement for esterification in order to be successfully transported by the Sertoli cells. Existing evidence suggests that both the Sertoli cells and the germinal cells have specific requirements for retinoids. In the vitamin A deficient rat there appears to be a developmental block at preleptotene spermatocyte and type Al spermatogonia stages. This block is removed by retinol and germinal cell development reinitiates in a synchronous manner. The synchronous testis model offers a number of advantages for the study of molecular events associated with the cycle of the seminiferous epithelium and the development of germinal cells as well as for investigations into the mechanism of action of the retinoids.
M D Griswold; P D Bishop; K H Kim; R Ping; J E Siiteri; C Morales
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  564     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  1989  
Date Detail:
Created Date:  1989-10-05     Completed Date:  1989-10-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  154-72     Citation Subset:  IM    
Program in Biochemistry and Biophysics, Washington State University, Pullman 99164.
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MeSH Terms
Amino Acid Sequence
Cells, Cultured
Electrophoresis, Gel, Two-Dimensional
Glycoproteins / genetics
Molecular Chaperones*
Molecular Sequence Data
Proteins / secretion
Seminiferous Tubules / cytology,  physiology*
Sertoli Cells / physiology
Testis / physiology*
Vitamin A / physiology*
Vitamin A Deficiency / pathology
Grant Support
Reg. No./Substance:
0/Clusterin; 0/Glycoproteins; 0/Molecular Chaperones; 0/Proteins; 11103-57-4/Vitamin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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