Document Detail


Function of vitamin A in normal and synchronized seminiferous tubules.
MedLine Citation:
PMID:  2672955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vitamin A is clearly an important factor in spermatogenesis. Some of the new data on metabolism of retinoids in the testis has contributed to our understanding of the mechanism(s) involved in the action of vitamin A. It is probable that the requirement of the testis of vitamin A deficient rats for retinol but not retinoic acid involves access of the retinoids to various testicular compartments. Retinol may be required by germinal cells because of a requirement for esterification in order to be successfully transported by the Sertoli cells. Existing evidence suggests that both the Sertoli cells and the germinal cells have specific requirements for retinoids. In the vitamin A deficient rat there appears to be a developmental block at preleptotene spermatocyte and type Al spermatogonia stages. This block is removed by retinol and germinal cell development reinitiates in a synchronous manner. The synchronous testis model offers a number of advantages for the study of molecular events associated with the cycle of the seminiferous epithelium and the development of germinal cells as well as for investigations into the mechanism of action of the retinoids.
Authors:
M D Griswold; P D Bishop; K H Kim; R Ping; J E Siiteri; C Morales
Related Documents :
10859245 - Pulsatile stimulation with recombinant single chain human luteinizing hormone elicits p...
3079675 - Sertoli cell membrane polypeptide composition is modulated by germ cells.
11764975 - Spermatogenesis by sisyphus: proliferating stem germ cells fail to repopulate the testi...
10614645 - Progesterone action in a murine leydig tumor cell line (mltc-1), possibly through a non...
6345445 - Defective ingestion of rod outer segments by cultured dystrophic rat pigment epithelial...
22319655 - Estrogens in male germ cells.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  564     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  1989  
Date Detail:
Created Date:  1989-10-05     Completed Date:  1989-10-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  154-72     Citation Subset:  IM    
Affiliation:
Program in Biochemistry and Biophysics, Washington State University, Pullman 99164.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Cells, Cultured
Clusterin
Electrophoresis, Gel, Two-Dimensional
Glycoproteins / genetics
Male
Molecular Chaperones*
Molecular Sequence Data
Proteins / secretion
Rats
Seminiferous Tubules / cytology,  physiology*
Sertoli Cells / physiology
Spermatogenesis
Testis / physiology*
Vitamin A / physiology*
Vitamin A Deficiency / pathology
Grant Support
ID/Acronym/Agency:
HD10808/HD/NICHD NIH HHS; HD21523/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Clusterin; 0/Glycoproteins; 0/Molecular Chaperones; 0/Proteins; 11103-57-4/Vitamin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Regulation of spermatogonial proliferation.
Next Document:  A profile of sickle cell disease in Nigeria.