| Function of vitamin A in normal and synchronized seminiferous tubules. | |
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MedLine Citation:
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PMID: 2672955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vitamin A is clearly an important factor in spermatogenesis. Some of the new data on metabolism of retinoids in the testis has contributed to our understanding of the mechanism(s) involved in the action of vitamin A. It is probable that the requirement of the testis of vitamin A deficient rats for retinol but not retinoic acid involves access of the retinoids to various testicular compartments. Retinol may be required by germinal cells because of a requirement for esterification in order to be successfully transported by the Sertoli cells. Existing evidence suggests that both the Sertoli cells and the germinal cells have specific requirements for retinoids. In the vitamin A deficient rat there appears to be a developmental block at preleptotene spermatocyte and type Al spermatogonia stages. This block is removed by retinol and germinal cell development reinitiates in a synchronous manner. The synchronous testis model offers a number of advantages for the study of molecular events associated with the cycle of the seminiferous epithelium and the development of germinal cells as well as for investigations into the mechanism of action of the retinoids. |
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Authors:
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M D Griswold; P D Bishop; K H Kim; R Ping; J E Siiteri; C Morales |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 564 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-10-05 Completed Date: 1989-10-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 154-72 Citation Subset: IM |
Affiliation:
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Program in Biochemistry and Biophysics, Washington State University, Pullman 99164. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Cells, Cultured Clusterin Electrophoresis, Gel, Two-Dimensional Glycoproteins / genetics Male Molecular Chaperones* Molecular Sequence Data Proteins / secretion Rats Seminiferous Tubules / cytology, physiology* Sertoli Cells / physiology Spermatogenesis Testis / physiology* Vitamin A / physiology* Vitamin A Deficiency / pathology |
| Grant Support | |
ID/Acronym/Agency:
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HD10808/HD/NICHD NIH HHS; HD21523/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Clusterin; 0/Glycoproteins; 0/Molecular Chaperones; 0/Proteins; 11103-57-4/Vitamin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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