| Function, structure and mechanism of bacterial photosensory LOV proteins. | |
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MedLine Citation:
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PMID: 21822294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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LOV (light, oxygen or voltage) domains are protein photosensors that are conserved in bacteria, archaea, plants and fungi, and detect blue light via a flavin cofactor. LOV domains are present in both chemotrophic and phototrophic bacterial species, in which they are found amino-terminally of signalling and regulatory domains such as sensor histidine kinases, diguanylate cyclases-phosphodiesterases, DNA-binding domains and regulators of RNA polymerase σ-factors. In this Review, we describe the current state of knowledge about the function of bacterial LOV proteins, the structural basis of LOV domain-mediated signal transduction, and the use of LOV domains as genetically encoded photoswitches in synthetic biology. |
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Authors:
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Julien Herrou; Sean Crosson |
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Publication Detail:
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Type: Journal Article; Review Date: 2011-08-08 |
Journal Detail:
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Title: Nature reviews. Microbiology Volume: 9 ISSN: 1740-1534 ISO Abbreviation: Nat. Rev. Microbiol. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-16 Completed Date: 2011-11-21 Revised Date: 2013-04-04 |
Medline Journal Info:
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Nlm Unique ID: 101190261 Medline TA: Nat Rev Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 713-23 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, The University of Chicago, Illinois 60637, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Archaea
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chemistry,
genetics,
metabolism Archaeal Proteins / chemistry, metabolism Bacteria* / chemistry, genetics, metabolism Bacterial Proteins* / chemistry, metabolism Cryptochromes Flavins / metabolism Flavoproteins / chemistry, metabolism Fungal Proteins / chemistry, metabolism Fungi / chemistry, genetics, metabolism Light Phototropins / metabolism Phototropism* Plant Proteins / chemistry, metabolism Plants / chemistry, genetics, metabolism Signal Transduction Synthetic Biology |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM087353/GM/NIGMS NIH HHS; R01 GM087353-03/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Archaeal Proteins; 0/Bacterial Proteins; 0/Cryptochromes; 0/Flavins; 0/Flavoproteins; 0/Fungal Proteins; 0/Phototropins; 0/Plant Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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