Document Detail

Function, structure and mechanism of bacterial photosensory LOV proteins.
MedLine Citation:
PMID:  21822294     Owner:  NLM     Status:  MEDLINE    
LOV (light, oxygen or voltage) domains are protein photosensors that are conserved in bacteria, archaea, plants and fungi, and detect blue light via a flavin cofactor. LOV domains are present in both chemotrophic and phototrophic bacterial species, in which they are found amino-terminally of signalling and regulatory domains such as sensor histidine kinases, diguanylate cyclases-phosphodiesterases, DNA-binding domains and regulators of RNA polymerase σ-factors. In this Review, we describe the current state of knowledge about the function of bacterial LOV proteins, the structural basis of LOV domain-mediated signal transduction, and the use of LOV domains as genetically encoded photoswitches in synthetic biology.
Julien Herrou; Sean Crosson
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-08-08
Journal Detail:
Title:  Nature reviews. Microbiology     Volume:  9     ISSN:  1740-1534     ISO Abbreviation:  Nat. Rev. Microbiol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-16     Completed Date:  2011-11-21     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  101190261     Medline TA:  Nat Rev Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  713-23     Citation Subset:  IM    
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MeSH Terms
Archaea / chemistry,  genetics,  metabolism
Archaeal Proteins / chemistry,  metabolism
Bacteria* / chemistry,  genetics,  metabolism
Bacterial Proteins* / chemistry,  metabolism
Flavins / metabolism
Flavoproteins / chemistry,  metabolism
Fungal Proteins / chemistry,  metabolism
Fungi / chemistry,  genetics,  metabolism
Phototropins / metabolism
Plant Proteins / chemistry,  metabolism
Plants / chemistry,  genetics,  metabolism
Signal Transduction
Synthetic Biology
Grant Support
Reg. No./Substance:
0/Archaeal Proteins; 0/Bacterial Proteins; 0/Cryptochromes; 0/Flavins; 0/Flavoproteins; 0/Fungal Proteins; 0/Phototropins; 0/Plant Proteins

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