Document Detail

Function of mucosa-associated lymphoid tissue in antibody formation.
MedLine Citation:
PMID:  20450282     Owner:  NLM     Status:  MEDLINE    
Abundant evidence supports the notion that human intestinal plasma cells are largely derived from B cells initially activated in gut-associated lymphoid tissue (GALT). Nevertheless, insufficient knowledge exists about the uptake, processing, and presentation of luminal antigens occurring in GALT to accomplish priming and sustained expansion of mucosal B cells. Also, it is unclear how the germinal center reaction so strikingly promotes class switch to IgA and expression of J chain, although the commensal microbiota appears to contribute to both diversification and memory. B-cell migration from GALT to the intestinal lamina propria is guided by rather well-defined adhesion molecules and chemokines/chemokine receptors, but the cues directing homing to secretory effector sites beyond the gut require better definition. In this respect, the role of human Waldeyer's ring (including adenoids and the palatine tonsils) as a regional mucosa-associated lymphoid tissue must be better defined, although the balance of evidence suggests that it functions as nasopharynx-associated lymphoid tissue (NALT) like the characteristic NALT structures in rodents. Altogether, data suggest a remarkable compartmentalization of the mucosal immune system that must be taken into account in the development of effective local vaccines to protect specifically the airways, small and large intestines, and the female genital tract.
Per Brandtzaeg
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunological investigations     Volume:  39     ISSN:  1532-4311     ISO Abbreviation:  Immunol. Invest.     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-08-13     Revised Date:  2010-09-23    
Medline Journal Info:
Nlm Unique ID:  8504629     Medline TA:  Immunol Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  303-55     Citation Subset:  IM    
Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Centre for Immune Regulation, University of Oslo, Department and Institute of Pathology, Oslo University Hospital, Rikshospitalet, N-0027 Oslo, Norway.
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MeSH Terms
Antibody Formation / immunology*
B-Lymphocytes / immunology
Immunity, Mucosal / immunology*
Lymphoid Tissue / cytology,  immunology*
Mucous Membrane / cytology,  immunology
Erratum In:
Immunol Invest. 2010;39(7):780

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