Document Detail


Function of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15.
MedLine Citation:
PMID:  7803808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The interleukin-2 (IL-2) receptor gamma-chain is a common component of several members of the cytokine receptor superfamily including those for IL-2, IL-4, IL-7, IL-9, IL-15, and possibly IL-13, and has recently been renamed the common gamma-chain (gamma c-chain). Transfection experiments have shown that the gamma c-chain participates in signal transduction by IL-2, IL-4 and IL-7, but a functional role for the gamma c-chain in biological responses by normal T cells and B cells to these cytokines has not been established. In this study, we have used X-linked severe combined immunodeficiency (X-SCID) as a naturally occurring gamma c-chain gene disruption model to examine the role of the gamma c-chain in human B-cell responses to IL-2, IL-4, IL-13, and IL-15. Our experiments show that B cells from two X-SCID patients with characterized gamma c-chain gene mutations do not respond to IL-2 or IL-15, but respond as well or better than normal B cells to both IL-4 and IL-13 in assays for B-cell activation, proliferation, and IgE secretion. This finding raises important questions about the function of the gamma c-chain in receptors for IL-4 and IL-13, and the nature of the immune defect in X-SCID.
Authors:
D J Matthews; P A Clark; J Herbert; G Morgan; R J Armitage; C Kinnon; A Minty; K H Grabstein; D Caput; P Ferrara
Related Documents :
11402618 - In vitro transmission of hcmv between fibroblasts and peripheral blood leukocytes in th...
2783328 - Modulation of il-2-induced human b cell proliferation in the presence of human 50-kda b...
9058798 - Human t helper cell differentiation is regulated by the combined action of cytokines an...
16280168 - Inhibition of interleukin-4 production in activated t cells via down-regulation of nf-a...
12061888 - Structure-activity relationship for enhancement of paracellular permeability across cac...
21239408 - Casparian bands occur in the periderm of pelargonium hortorum stem and root.
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood     Volume:  85     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-02-02     Completed Date:  1995-02-02     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  38-42     Citation Subset:  AIM; IM    
Affiliation:
Cellular Immunology Unit, Institute of Child Health, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
B-Lymphocytes / immunology
Cell Division
Humans
Immunoglobulin E / metabolism
Infant
Interleukin-13 / pharmacology
Interleukin-15
Interleukin-2 / pharmacology
Interleukin-4 / pharmacology
Interleukins / pharmacology*
Linkage (Genetics)
Lymphocyte Activation
Male
Mutation
Polymerase Chain Reaction
Receptors, Interleukin-2 / chemistry,  physiology*
Severe Combined Immunodeficiency / genetics,  immunology*
Structure-Activity Relationship
X Chromosome*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Interleukin-13; 0/Interleukin-15; 0/Interleukin-2; 0/Interleukins; 0/Receptors, Interleukin-2; 207137-56-2/Interleukin-4; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Long-term outcome of aplastic anemia in adults treated with antithymocyte globulin: comparison with ...
Next Document:  Erythropoietin and interleukin-3 induce distinct events in erythropoietin receptor-expressing BA/F3 ...