Document Detail


Function of human intrinsic cardiac neurons in situ.
MedLine Citation:
PMID:  11353678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We sought to determine the behavior of intrinsic cardiac neurons in human subjects undergoing cardiac surgery and to correlate their activity with hemodynamics status. A lead II electrocardiogram, pulmonary artery pressure, and systemic arterial pressure were recorded along with extracellular activity generated by right atrial neurons in 10 patients undergoing coronary artery bypass surgery. Identified neurons generated spontaneously activity that was, for the most part, unrelated to the cardiac cycle. Most neurons were activated by gentle mechanical distortion of ventricular epicardial loci. The activity generated by neurons in each patient increased when arterial pressure increased and decreased when arterial pressure fell. Intrinsic cardiac neurons continued to generate activity during cardioplegia and cardiopulmonary bypass, but at reduced levels. Normal neuronal activity was restored postbypass. It is concluded that human intrinsic cardiac neurons generate spontaneous activity and that many receive inputs from ventricular mechanosensory neurites. The latter may account for the fact that their behavior depends, in part, on cardiac dynamics. They are also sensitive to intravenously administered pharmacological agents. These data also indicate that cardiopulmonary bypass and cardioplegia do not induce residual depression of their function.
Authors:
R C Arora; G M Hirsch; K Johnson Hirsch; C Hancock Friesen; J A Armour
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  280     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-05-16     Completed Date:  2001-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1736-40     Citation Subset:  IM    
Affiliation:
Department of Surgery, Dalhousie University, Halifax, Nova Scotia, B3H 4H7, Canada.
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MeSH Terms
Descriptor/Qualifier:
Aged
Blood Pressure / physiology
Coronary Artery Bypass
Coronary Disease / physiopathology,  surgery
Female
Heart Arrest, Induced
Heart Conduction System / pathology,  physiopathology*
Humans
Intraoperative Period
Male
Middle Aged
Neurons / physiology*
Neurons, Afferent / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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