| Function and activation of the transcription factor NF-kappa B in the response to toxins and pathogens. | |
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MedLine Citation:
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PMID: 8597085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ubiquitous transcription factor NF-kappa B regulates the expression of a plethora of genes. In most cell types the dimeric DNA-binding form of the transcription factor is retained in the cytoplasm by physical association with the inhibitory I kappa B molecules. Five distinct DNA-binding subunits have so far been identified in vertebrates, which share a N-terminal homology region responsible for DNA-binding and dimerization. Exposure of cells to a variety of pathogenic and/or toxic agents leads to the generation of hydrogen peroxide and the inducible phosphorylation of I kappa B, which is a prerequisite for its proteolytic degradation. The DNA-binding subunits can subsequently enter the nucleus, bind to their cognate DNA and activate transcription. |
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Authors:
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M L Schmitz |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Toxicology letters Volume: 82-83 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-04-15 Completed Date: 1996-04-15 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 407-11 Citation Subset: IM |
Affiliation:
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Institute of Biochemistry, Albert-Ludwigs-University, Freiburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals DNA / metabolism Humans NF-kappa B / physiology* Reactive Oxygen Species Toxins, Biological / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/NF-kappa B; 0/Reactive Oxygen Species; 0/Toxins, Biological; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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