Document Detail


Function of Sox2 in ependymal cells of lesioned spinal cords in adult zebrafish.
MedLine Citation:
PMID:  25150399     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The sex-determining region Y-box 2 (Sox2) is related not only to pluripotency, but also to cell proliferation. Zebrafish can regain their motor function after spinal cord injury (SCI). Following SCI, new motor neurons are produced from proliferating ependymal cells. Here, we investigated the expression and function of Sox2 after SCI in zebrafish. Sox2 was upregulated as early as 1 day post-lesion (dpl) in ependymal cells, which was followed by cell proliferation. Sox2 knockdown significantly decreased the number of proliferating cells at 5 dpl. The results of this study suggest a role of Sox2 as one of the proliferation initiators in ependymal cells after SCI.
Authors:
Kazuhiro Ogai; Kumi Nakatani; Suguru Hisano; Kayo Sugitani; Yoshiki Koriyama; Satoru Kato
Related Documents :
25150399 - Function of sox2 in ependymal cells of lesioned spinal cords in adult zebrafish.
2158279 - Partial characterization of a collagen-binding, differentiation-related glycoprotein fr...
2864959 - Phosphorylation and sulfation of arylsulfatase a accompanies biosynthesis of the enzyme...
7983459 - Relationship between chromosome aberrations, micronuclei and cell kill in two human tum...
10861449 - Expression of her/erbb family of receptor tyrosine kinases and induction of differentia...
18671849 - Effects of cox-2 inhibition on expression of vascular endothelial growth factor and int...
21683999 - Hydrogel-based biomimetic environment for in vitro modulation of branching morphogenesis.
24350919 - Proteomics of cancer stem cells.
24489319 - A8.14 effect of rituximab on b-cell phenotypes and on b-cell activating factor receptor...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-20
Journal Detail:
Title:  Neuroscience research     Volume:  -     ISSN:  1872-8111     ISO Abbreviation:  Neurosci. Res.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500749     Medline TA:  Neurosci Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ireland Ltd.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Role of epigenetic factors in the development of mental illness throughout life.
Next Document:  Small effect of upcoming reward outcomes on visual cue-related neuronal activity in macaque area TE ...