Document Detail

Fumonisins: their implications for human and animal health.
MedLine Citation:
PMID:  7582616     Owner:  NLM     Status:  MEDLINE    
Fusarium moniliforme is one of the predominant fungi associated with corn intended for human and animal consumption world-wide. Fumonisins, food-borne carcinogens that occur naturally in corn, were first isolated and chemically characterized in South Africa in 1988. The major metabolite, fumonisin B1 (FB1), was subsequently shown to cause leukoencephalomalacia (LEM) in horses, pulmonary edema syndrome (PES) in pigs, and liver cancer in rats. FB1 is also a cancer promoter and initiator in rat liver; hepatotoxic to horses, pigs, rats, and vervet monkeys; cytotoxic to mammalian cell cultures; and phytotoxic to several plants. Fumonisins in home-grown corn have been associated with an elevated risk for human esophageal cancer in Transkei and China. There is a close structural similarity between fumonisin and sphingosine, and fumonisins are the first known naturally occurring inhibitors of sphingolipid biosynthesis. The natural occurrence of FB1, together with FB2 and FB3, has been reported in commercial corn and/or corn-based feeds and foods from Argentina, Australia, Brazil, Botswana, Bulgaria, Canada, China, Egypt, France, Italy, Japan, Kenya, Hungary, Nepal, Peru, South Africa, Switzerland, United States, and Zimbabwe. It is imperative that safe levels of fumonisins in human foods and animal feeds should be determined and realistic tolerance levels established as soon as possible.
W F Marasas
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Natural toxins     Volume:  3     ISSN:  1056-9014     ISO Abbreviation:  Nat. Toxins     Publication Date:  1995  
Date Detail:
Created Date:  1995-12-14     Completed Date:  1995-12-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9212382     Medline TA:  Nat Toxins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  193-8; discussion 221     Citation Subset:  IM    
Programme on Mycotoxins and Experimental Carcinogenesis, Medical Research Council, Tygerberg, South Africa.
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MeSH Terms
Carcinogens, Environmental / toxicity*
Food Microbiology
Mycotoxins / toxicity*
Zea mays / microbiology
Reg. No./Substance:
0/Carcinogens, Environmental; 0/Fumonisins; 0/Mycotoxins; 116355-83-0/fumonisin B1; 116355-84-1/fumonisin B2; 136379-59-4/fumonisin B3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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