| Fumonisins: fungal toxins that shed light on sphingolipid function. | |
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MedLine Citation:
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PMID: 15157459 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Fumonisins are sphinganine analogues produced by Fusarium moniliforme and related fungi. They inhibit ceramide synthase and block the biosynthesis o f complex sphingolipids, promoting accumulation o f sphinganine and sphinganine 1 phosphate. Disruption o f sphingolipid metabolism by fumonisin B(1) alters cell-cell interactions, the behaviour o f cell-surface proteins, the activity o f protein kinases, the metabolism of other lipids, and cell growth and viability. This multitude of effects probably accounts for the toxicity and carcinogenicity of these mycotoxins. Naturally occurring inhibitors o f sphingolipid metabolism such as fumonisins are proving to be powerful tools for studying the diverse roles of sphingolipids in cell regulation and disease. |
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Authors:
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A H Merrill; D C Liotta; R T Riley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Trends in cell biology Volume: 6 ISSN: 0962-8924 ISO Abbreviation: Trends Cell Biol. Publication Date: 1996 Jun |
Date Detail:
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Created Date: 2004-05-25 Completed Date: 2005-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200566 Medline TA: Trends Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 218-23 Citation Subset: - |
Affiliation:
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US Dept of Agriculture, Agriculture Research Service, Toxicology and Mycotoxins Research Unit, Athens, GA 30613, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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