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Fumonisins: fungal toxins that shed light on sphingolipid function.
MedLine Citation:
PMID:  15157459     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Fumonisins are sphinganine analogues produced by Fusarium moniliforme and related fungi. They inhibit ceramide synthase and block the biosynthesis o f complex sphingolipids, promoting accumulation o f sphinganine and sphinganine 1 phosphate. Disruption o f sphingolipid metabolism by fumonisin B(1) alters cell-cell interactions, the behaviour o f cell-surface proteins, the activity o f protein kinases, the metabolism of other lipids, and cell growth and viability. This multitude of effects probably accounts for the toxicity and carcinogenicity of these mycotoxins. Naturally occurring inhibitors o f sphingolipid metabolism such as fumonisins are proving to be powerful tools for studying the diverse roles of sphingolipids in cell regulation and disease.
Authors:
A H Merrill; D C Liotta; R T Riley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Trends in cell biology     Volume:  6     ISSN:  0962-8924     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  2004-05-25     Completed Date:  2005-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  218-23     Citation Subset:  -    
Affiliation:
US Dept of Agriculture, Agriculture Research Service, Toxicology and Mycotoxins Research Unit, Athens, GA 30613, USA.
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