Document Detail

Fumonisin b1: a neurotoxic mycotoxin / fumonizin b1: neurotoksični mikotoksin.
MedLine Citation:
PMID:  23334049     Owner:  NLM     Status:  In-Data-Review    
Abstract Fumonisin B1 (FB1) is a mycotoxin produced by Fusarium spp. moulds that contaminate crop, predominantly maize, all around the world. More than 15 types of fumonisins have been indentified so far, but FB1 is the most abundant and toxicologically the most significant one. FB1 has a wide range of toxic effects, depending on animal species. In horses FB1 causes equine leukoencephalomalacia (ELEM), in pigs pulmonary oedema and in experimental rodents nephrotoxicity and hepatotoxicity. In humans exposure to FB1 is linked with higher incidence of primary liver cancer and oesophageal cancer, which are frequent in certain regions of the world (such as Transkei region in South Africa) where maize is staple food. The occurrence of neural tube defect in children in some countries of Central America (such as Mexico and Honduras) is connected with the consumption of FB1-contaminated maize-based food. However, possible involvement of FB1 in the development of human diseases is not clear. Nevertheless, the International Agency for Research on Cancer (IARC) has classified FB1 as a possible carcinogen to humans (group 2B). FB1 is a causative agent of ELEM, a brain disorder in equines, indicating that brain is a target organ of FB1 toxicity. Several studies on experimental animals or on cell cultures of neural origin have established that FB1 has a neurodegenerative potential, although the mechanism of its neurotoxicity is still vague. The aim of this article is to give an overview of available literature on FB1 neurotoxicity and involved mechanisms, and to offer a new perspective for future studies.
Ana-Marija Domijan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arhiv za higijenu rada i toksikologiju     Volume:  63     ISSN:  0004-1254     ISO Abbreviation:  Arh Hig Rada Toksikol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373100     Medline TA:  Arh Hig Rada Toksikol     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  531-44     Citation Subset:  IM    
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