Document Detail


Fumonisin B(1) is genotoxic in human derived hepatoma (HepG2) cells.
MedLine Citation:
PMID:  11971998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fumonisin B(1) (FB(1)), a widespread Fusarium toxin which is frequently found in corn, causes liver tumors in laboratory rodents and is a suspected human carcinogen. The compound was tested in micronucleus (MN) and single cell gel electrophoresis (SCGE) assays in human derived hepatoma (HepG2) cells and caused a pronounced dose-dependent genotoxic effect at exposure concentrations > or = 25 microg/ml. In contrast, no induction of his(+) revertants was found in Salmonella microsome assays with strains TA98, TA100, TA102, TA1535 and TA1537 upon addition of HepG2-derived enzyme (S9) mix in liquid incubation assays with identical exposure concentrations. Taken together, our results indicate that FB(1) is clastogenic in human derived cells. This observation supports the assumption that this compound may act as a genotoxic carcinogen in humans.
Authors:
Veronika Ehrlich; Firouz Darroudi; Maria Uhl; Hans Steinkellner; Markus Zsivkovits; Siegfried Knasmueller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutagenesis     Volume:  17     ISSN:  0267-8357     ISO Abbreviation:  Mutagenesis     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-04-24     Completed Date:  2002-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8707812     Medline TA:  Mutagenesis     Country:  England    
Other Details:
Languages:  eng     Pagination:  257-60     Citation Subset:  IM    
Affiliation:
Institute of Cancer Research, University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Carcinogens, Environmental*
Carcinoma, Hepatocellular / metabolism*
Comet Assay
Dose-Response Relationship, Drug
Fumonisins*
Humans
Kinetics
Micronucleus Tests
Models, Chemical
Mutagens*
Time Factors
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Carcinogens, Environmental; 0/Fumonisins; 0/Mutagens; 116355-83-0/fumonisin B1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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