| Fumonisin B1 toxicity in grower-finisher pigs: a comparative analysis of genetically engineered Bt corn and non-Bt corn by using quantitative dietary exposure assessment modeling. | |
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MedLine Citation:
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PMID: 21909298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, we investigate the long-term exposure (20 weeks) to fumonisin B(1) (FB(1)) in grower-finisher pigs by conducting a quantitative exposure assessment (QEA). Our analytical approach involved both deterministic and semi-stochastic modeling for dietary comparative analyses of FB(1) exposures originating from genetically engineered Bacillus thuringiensis (Bt)-corn, conventional non-Bt corn and distiller's dried grains with solubles (DDGS) derived from Bt and/or non-Bt corn. Results from both deterministic and semi-stochastic demonstrated a distinct difference of FB(1) toxicity in feed between Bt corn and non-Bt corn. Semi-stochastic results predicted the lowest FB(1) exposure for Bt grain with a mean of 1.5 mg FB(1)/kg diet and the highest FB(1) exposure for a diet consisting of non-Bt grain and non-Bt DDGS with a mean of 7.87 mg FB(1)/kg diet; the chronic toxicological incipient level of concern is 1.0 mg of FB(1)/kg of diet. Deterministic results closely mirrored but tended to slightly under predict the mean result for the semi-stochastic analysis. This novel comparative QEA model reveals that diet scenarios where the source of grain is derived from Bt corn presents less potential to induce FB(1) toxicity than diets containing non-Bt corn. |
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Authors:
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James E Delgado; Jeffrey D Wolt |
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Publication Detail:
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Type: Journal Article Date: 2011-07-28 |
Journal Detail:
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Title: International journal of environmental research and public health Volume: 8 ISSN: 1660-4601 ISO Abbreviation: Int J Environ Res Public Health Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-09-12 Completed Date: 2012-01-16 Revised Date: 2012-04-26 |
Medline Journal Info:
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Nlm Unique ID: 101238455 Medline TA: Int J Environ Res Public Health Country: Switzerland |
Other Details:
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Languages: eng Pagination: 3179-90 Citation Subset: IM |
Affiliation:
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Interdepartmental Toxicology Program, Department of Agronomy, Iowa State University, Ames, IA 50011, USA. jdelgado@iastate.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed
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analysis* Animal Nutritional Physiological Phenomena Animals Bacillus thuringiensis / genetics*, metabolism Bacterial Proteins / genetics, metabolism Body Composition Body Weight Diet / veterinary* Environmental Exposure* Fumonisins / analysis, toxicity* Models, Biological Plants, Genetically Modified / genetics Stochastic Processes Sus scrofa / growth & development* Zea mays / genetics |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Fumonisins; 116355-83-0/fumonisin B1 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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