| Fulminant postpartum cerebral vasoconstriction syndrome. | |
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MedLine Citation:
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PMID: 22232351 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To raise awareness of the potentially adverse consequences of postpartum cerebral vasoconstriction, which is typically considered benign and self-limiting, by describing 4 fulminantly fatal cases. DESIGN: Retrospective case series. SETTING: Tertiary referral center. Patients Four postpartum women aged 15 to 33 years developed acute neurologic deficits 1 to 8 days after uncomplicated deliveries. One had a history of migraine headaches and 2 had histories of spontaneous abortion. Two of the patients had uneventful pregnancies and 2 had preeclampsia, 1 of whom had acute hepatic failure. Presenting symptoms included severe headache (n = 3), focal deficit (n = 1), seizure (n = 1), and encephalopathy (n = 1). Initial brain imaging results demonstrated cortical ischemia and global edema in 2 patients, lobar hemorrhage in 1, and normal findings in 1. All had rapid clinical deterioration from hours to days with multiterritorial infarctions and global brain edema on imaging. All had angiographic findings of diffuse, severe, segmental multifocal arterial narrowings. INTERVENTIONS: Aggressive treatment was attempted with most patients including intravenous magnesium sulfate, corticosteroids, calcium channel blockers, balloon angioplasty, vasopressors, and osmotic agents. Two patients underwent serial angiography, with results showing severe, recurrent proximal vasoconstriction involving all major intracranial vessels. RESULTS: All patients had fulminant, accelerating courses leading to their deaths within 8 to 24 days after delivery. CONCLUSIONS: Postpartum vasoconstriction can be fatal, with rapid progression of vasoconstriction, ischemia, and brain edema. Clinicians need to be aware of the potential consequences of this condition. Postpartum women with acute neurologic symptoms require prompt investigation with noninvasive cerebrovascular imaging and close monitoring for possible secondary deterioration. |
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Authors:
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Jennifer E Fugate; Eelco F M Wijdicks; Joseph E Parisi; David F Kallmes; Harry J Cloft; Kelly D Flemming; Elias A Giraldo; Alejandro A Rabinstein |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of neurology Volume: 69 ISSN: 1538-3687 ISO Abbreviation: Arch. Neurol. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 111-7 Citation Subset: AIM; IM |
Affiliation:
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Mayo Clinic 8-W, 200 First Street SW, Rochester, MN 55905. rabinstein.alejandro@mayo.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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