Document Detail


Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene.
MedLine Citation:
PMID:  2181319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PRIMARY hypertension is a polygenic condition in which blood pressure is enigmatically elevated; it remains a leading cause of cardiovascular disease and death due to cerebral haemorrhage, cardiac failure and kidney disease. The genes for several of the proteins involved in blood pressure homeostasis have been cloned and characterized, including those of the renin-angiotensin system, which plays a central part in blood pressure control. Here we describe the introduction of the mouse Ren-2 renin gene into the genome of the rat and demonstrate that expression of this gene causes severe hypertension. These transgenic animals represent a model for hypertension in which the genetic basis for the disease is known. Further, as the transgenic animals do not overexpress active renin in the kidney and have low levels of active renin in their plasma, they also provide a new model for low-renin hypertension.
Authors:
J J Mullins; J Peters; D Ganten
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature     Volume:  344     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-05-07     Completed Date:  1990-05-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  541-4     Citation Subset:  IM    
Affiliation:
German Institute for High Blood Pressure Research, University of Heidelberg.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / metabolism
Angiotensin I / blood
Angiotensin II / blood
Animals
Animals, Genetically Modified
Disease Models, Animal*
Enzyme Precursors / blood
Gene Expression
Hypertension / genetics*,  metabolism
Kidney / metabolism
Mice
Mice, Inbred DBA
Rats
Renin / blood,  genetics*,  metabolism
Submandibular Gland / enzymology
Transfection
Chemical
Reg. No./Substance:
0/Enzyme Precursors; 11128-99-7/Angiotensin II; 9041-90-1/Angiotensin I; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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