| Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. | |
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MedLine Citation:
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PMID: 2181319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PRIMARY hypertension is a polygenic condition in which blood pressure is enigmatically elevated; it remains a leading cause of cardiovascular disease and death due to cerebral haemorrhage, cardiac failure and kidney disease. The genes for several of the proteins involved in blood pressure homeostasis have been cloned and characterized, including those of the renin-angiotensin system, which plays a central part in blood pressure control. Here we describe the introduction of the mouse Ren-2 renin gene into the genome of the rat and demonstrate that expression of this gene causes severe hypertension. These transgenic animals represent a model for hypertension in which the genetic basis for the disease is known. Further, as the transgenic animals do not overexpress active renin in the kidney and have low levels of active renin in their plasma, they also provide a new model for low-renin hypertension. |
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Authors:
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J J Mullins; J Peters; D Ganten |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nature Volume: 344 ISSN: 0028-0836 ISO Abbreviation: Nature Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-05-07 Completed Date: 1990-05-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0410462 Medline TA: Nature Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 541-4 Citation Subset: IM |
Affiliation:
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German Institute for High Blood Pressure Research, University of Heidelberg. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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metabolism Angiotensin I / blood Angiotensin II / blood Animals Animals, Genetically Modified Disease Models, Animal* Enzyme Precursors / blood Gene Expression Hypertension / genetics*, metabolism Kidney / metabolism Mice Mice, Inbred DBA Rats Renin / blood, genetics*, metabolism Submandibular Gland / enzymology Transfection |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Precursors; 11128-99-7/Angiotensin II; 9041-90-1/Angiotensin I; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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