Document Detail


Fulminant hyperkalaemia and multiple complications following ibuprofen overdose.
MedLine Citation:
PMID:  2601619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A previously healthy 17-year-old man was admitted in coma following major overdosage with ibuprofen and minor overdosage of doxepin (plasma concentrations 809 and 0.49 mg/L, respectively). Initially, potassium chloride (20 mmol 3-hourly) was infused because of mild hypokalaemia (K+ 2.8 mmol/L). 14 hours after admission the patient developed a hypermetabolic state with pyrexia, metabolic acidosis and progressive respiratory failure despite ventilation at 16 L/min, and a malignant broad complex tachycardia was associated with acute hyperkalaemia (K+ 8.3 mmol/L). The arrhythmia resolved with correction of the hyperkalaemia. Chest x-rays showed diffuse opacification throughout both lung fields and subsequently there was transient impairment of renal function, with evidence of mild rhabdomyolysis. Ventilatory support was required for 60 hours and a chest x-ray at 6 days showed extensive bilateral nodular shadowing, which was still present at follow-up 4 weeks later.
Authors:
D G Menzies; A G Conn; I J Williamson; L F Prescott
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Medical toxicology and adverse drug experience     Volume:  4     ISSN:  0113-5244     ISO Abbreviation:  Med Toxicol Adverse Drug Exp     Publication Date:    1989 Nov-Dec
Date Detail:
Created Date:  1990-01-30     Completed Date:  1990-01-30     Revised Date:  2014-07-25    
Medline Journal Info:
Nlm Unique ID:  8709214     Medline TA:  Med Toxicol Adverse Drug Exp     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  468-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Humans
Hypercalcemia / chemically induced*
Ibuprofen / poisoning*
Male
Chemical
Reg. No./Substance:
WK2XYI10QM/Ibuprofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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