Document Detail

Fulminant Wegener's granulomatosis presenting as epistaxis.
MedLine Citation:
PMID:  17351208     Owner:  NLM     Status:  MEDLINE    
The case of a 63-year-old woman who presented to the emergency department with epistaxis and haemodynamic instability is reported. Subsequent investigation showed renal failure and multiple pulmonary nodules. A positive proteinase 3 antineutrophil cytoplasmic antibody test supported the diagnosis of fulminant Wegener's granulomatosis, requiring urgent dialysis, plasma exchange and immunosuppression. This is the first report in the emergency literature of Wegener's granulomatosis presenting as acute epistaxis. Emergency physicians should consider Wegener's granulomatosis in patients with atypical epistaxis. In patients presenting with clinically severe, active disease early proteinase 3 antineutrophil cytoplasmic antibody testing is recommended.
Ankur Thapar; Ajith George; Andrew Pfleiderer
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Emergency medicine journal : EMJ     Volume:  24     ISSN:  1472-0213     ISO Abbreviation:  Emerg Med J     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-12     Completed Date:  2007-06-05     Revised Date:  2010-09-15    
Medline Journal Info:
Nlm Unique ID:  100963089     Medline TA:  Emerg Med J     Country:  England    
Other Details:
Languages:  eng     Pagination:  e14     Citation Subset:  IM    
Department of Otorhinolaryngology, Peterborough & Stamford NHS Trust, Peterborough, UK.
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MeSH Terms
Autoantibodies / analysis
Biological Markers / analysis
Epistaxis / etiology*
Kidney Failure, Chronic / etiology
Lung Diseases / etiology,  radiography
Middle Aged
Myeloblastin / immunology
Tomography, X-Ray Computed
Wegener Granulomatosis / complications*,  diagnosis
Reg. No./Substance:
0/Autoantibodies; 0/Biological Markers; EC

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