Document Detail

Fulminant Rocky Mountain spotted fever. Its pathologic characteristics associated with glucose-6-phosphate dehydrogenase deficiency.
MedLine Citation:
PMID:  6687526     Owner:  NLM     Status:  MEDLINE    
Three patients with documented fulminant Rocky Mountain spotted fever (RMSF) (death on or before day 5 of illness) had severe multisystemic injury as shown by clinical signs and laboratory data, but on microscopic examination showed minimal evidence of the typical mononuclear leukocytic response to rickettsial vascular infection and injury. Thrombosis was more extensive than in classic RMSF, with fibrin thrombi located in foci of rickettsial infection. These patients had a rash either preterminally or not at all, particularly severe Rickettsia-associated pulmonary lesions, and other shock-related lesions, eg, centrilobular hepatic necrosis. All three patients were male blacks with glucose-6-phosphate dehydrogenase deficiency, a condition recently associated with severity of RMSF. Diagnosis of fulminant RMSF requires awareness of its pathologic and epidemiologic aspects, and use of rickettsial isolation or specific immunofluorescence.
D H Walker; H K Hawkins; P Hudson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  107     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  121-5     Citation Subset:  AIM; IM    
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MeSH Terms
Brain / pathology
Glucosephosphate Dehydrogenase Deficiency / etiology*
Hepatomegaly / etiology
Kidney / pathology
Liver / pathology
Pulmonary Edema / etiology
Purpura / etiology
Rocky Mountain Spotted Fever / complications*,  pathology
Seizures / etiology
Spleen / pathology
Splenomegaly / etiology
Tachycardia / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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