Document Detail


Fulminant Rocky Mountain spotted fever. Its pathologic characteristics associated with glucose-6-phosphate dehydrogenase deficiency.
MedLine Citation:
PMID:  6687526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three patients with documented fulminant Rocky Mountain spotted fever (RMSF) (death on or before day 5 of illness) had severe multisystemic injury as shown by clinical signs and laboratory data, but on microscopic examination showed minimal evidence of the typical mononuclear leukocytic response to rickettsial vascular infection and injury. Thrombosis was more extensive than in classic RMSF, with fibrin thrombi located in foci of rickettsial infection. These patients had a rash either preterminally or not at all, particularly severe Rickettsia-associated pulmonary lesions, and other shock-related lesions, eg, centrilobular hepatic necrosis. All three patients were male blacks with glucose-6-phosphate dehydrogenase deficiency, a condition recently associated with severity of RMSF. Diagnosis of fulminant RMSF requires awareness of its pathologic and epidemiologic aspects, and use of rickettsial isolation or specific immunofluorescence.
Authors:
D H Walker; H K Hawkins; P Hudson
Related Documents :
21883676 - Changes in lung composition and regional perfusion and tissue distribution in patients ...
18782966 - Conservative management outcomes of traumatic acute subdural hematomas.
7650256 - Thyroid and thymic endocrine function and survival in severely traumatized patients wit...
22196796 - Adaptive radiotherapy using helical tomotherapy for head and neck cancer in definitive ...
21051856 - Multidetector row computed tomography to assess changes in airways linked to asthma con...
3348966 - Effect of puva on intestinal calcium absorption.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  107     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  121-5     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Aged
Brain / pathology
Child
Glucosephosphate Dehydrogenase Deficiency / etiology*
Hepatomegaly / etiology
Humans
Kidney / pathology
Liver / pathology
Male
Pulmonary Edema / etiology
Purpura / etiology
Rocky Mountain Spotted Fever / complications*,  pathology
Seizures / etiology
Spleen / pathology
Splenomegaly / etiology
Tachycardia / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mycotic aortic aneurysm. A complication of Campylobacter fetus septicemia.
Next Document:  Rheumatoid meningitis. A case report and review of the literature.