| Fulminant and Fatal Course of Acute Lymphoblastic Leukemia Due to Lactic Acidosis and Suspected Abdominal Compartment Syndrome. | |
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MedLine Citation:
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PMID: 22134616 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and its prognosis has considerably improved over the past 2 decades due to new therapeutic approaches. In some cases, however, it can develop very rapidly and cause possibly fatal complications. We report on the case of an 11-year-old boy with ALL, who rapidly developed severe lactic acidosis and abdominal compartment syndrome. He died of multiorgan failure only 5 days after diagnosis of ALL had been established. Autopsy revealed systemic leukemic infiltrations. We suppose that the mass of tumor cells induced a cascade of metabolic and endocrine reactions, which not only triggered the rapid progression of the disease but were also accountable for the lack of response to treatment. The pathophysiology of abdominal compartment syndrome as a rare and in our case ultimately fatal complication of ALL is described. |
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Authors:
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Friederike Terpe; Manuela Siekmeyer; Uta Bierbach; Werner Siekmeyer; Jürgen Kratzsch; Holger Till; Christian Wittekind; Wieland Kiess |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-29 |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: - ISSN: 1536-3678 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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*Hospital for Children and Adolescents †Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics ‡Department of Pediatric Surgery §Institute of Pathology, University of Leipzig, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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