| Fully-mature antral mouse oocytes are transcriptionally silent but their heterochromatin maintains a transcriptional permissive histone acetylation profile. | |
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MedLine Citation:
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PMID: 21468653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The final stages of antral mouse oocytes maturation are characterised by the transition from transcriptionally active NSN to inactive SN oocytes. Here, we studied the profile of histone acetylation changes occurring during the NSN-to-SN transition. METHODS: During the NSN-to-SN transition, oocytes were classified based on their chromatin organisation and the immunocytochemical profile of histones H2B, H3 and H4 acetylation was analysed. RESULTS: We described four patterns of immunostaining common to the three acetylated histones, corresponding to stages of progressive localisation: From a diffused distribution in NSN oocytes to the association with constitutive heterochromatin and then to the nucleolar surface region in SN oocytes. CONCLUSIONS: The maintenance of a favourable transcriptional epigenetic context, in the heterochromatin of transcriptionally silent SN oocytes, might be related to the early stages of development when transcripts from these heterochromatic regions are functional to preimplantation progression. |
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Authors:
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Maurizio Zuccotti; Michele Bellone; Frank Longo; Carlo Alberto Redi; Silvia Garagna |
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Publication Detail:
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Type: Journal Article Date: 2011-04-06 |
Journal Detail:
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Title: Journal of assisted reproduction and genetics Volume: 28 ISSN: 1573-7330 ISO Abbreviation: J. Assist. Reprod. Genet. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-19 Completed Date: 2012-11-13 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 9206495 Medline TA: J Assist Reprod Genet Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1193-6 Citation Subset: IM |
Affiliation:
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Sezione di Istologia ed Embriologia, Dipartimento di Medicina Sperimentale, Universita' degli Studi di Parma, Parma, Italy. maurizio.zuccotti@unipr.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylation Animals Female Gene Silencing Heterochromatin / genetics, metabolism* Histones / metabolism* Mice Mice, Inbred Strains Oocytes / cytology*, metabolism Transcription, Genetic* |
| Chemical | |
Reg. No./Substance:
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0/Heterochromatin; 0/Histones |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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