Document Detail

Fully autonomous preload-sensitive control of implantable rotary blood pumps.
MedLine Citation:
PMID:  20883392     Owner:  NLM     Status:  MEDLINE    
A pulsatility-based control algorithm with a self-adapting pulsatility reference value is proposed for an implantable rotary blood pump and is to be tested in computer simulations. The only input signal is the pressure difference across the pump, which is deduced from measurements of the pump's magnetic bearing. A pulsatility index (PI) is calculated as the mean absolute deviation from the mean pressure difference. As a second characteristic, the gradient of the PI with respect to the pump speed is derived. This pulsatility gradient (GPI) is used as the controlled variable to adjust the operating point of the pump when physiological variables such as the systemic arterial pressure, left ventricular contractility, or heart rate change. Depending on the selected mode of operation, the controller is either a linear controller or an extremum-seeking controller. A supervisory mechanism monitors the state of the system and projects the system into the region of convergence when necessary. The controller of the GPI continuously adjusts the reference value for PI. An underlying robust linear controller regulates the PI to the reference value in order to take into account changes in pulmonary venous return. As a means of reacting to sudden changes in the venous return, a suction detection mechanism was included. The control system is robustly stable within a wide range of physiological variables. All the clinician needs to do is to select between the two operating modes. No other adjustments are required. The algorithm showed promising results which encourage further testing in vitro and in vivo.
Andreas Arndt; Peter Nüsser; Bernhard Lampe
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Artificial organs     Volume:  34     ISSN:  1525-1594     ISO Abbreviation:  Artif Organs     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-01     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  726-35     Citation Subset:  IM    
Copyright Information:
© 2010, Copyright the Authors. Artificial Organs © 2010, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.
Berlin Heart-R&D, Berlin, Germany.
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MeSH Terms
Blood Pressure
Computer Simulation
Heart Failure / physiopathology,  therapy*
Heart Rate
Heart-Assist Devices*
Models, Cardiovascular
Myocardial Contraction
Prosthesis Design
Pulsatile Flow
Signal Processing, Computer-Assisted*
Time Factors
Ventricular Function, Left

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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