| Fully automated one-pot radiosynthesis of O-(2-[(18)F]fluoroethyl)-l-tyrosine on the TracerLab FX(FN) module. | |
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MedLine Citation:
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PMID: 21718939 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: An efficient fully automated method for the radiosynthesis of enantiomerically pure O-(2-[(18)F]fluoroethyl)-l-tyrosine ([(18)F]FET) using the GE TracerLab FX(FN) synthesis module via the O-(2-tosyloxyethyl)-N-trityl-l-tyrosine tert-butylester precursor has been developed. METHODS: The radiolabelling of [(18)F]FET involved a classical [(18)F]fluoride nucleophilic substitution performed in acetonitrile using potassium carbonate and Kryptofix 222, followed by acid hydrolysis using 2N hydrochloric acid. RESULTS: [(18)F]FET was produced in 35±5% (n=22) yield non-decay-corrected (55±5% decay-corrected) and with radiochemical and enantiomeric purity of >99% with a specific activity of >90 GBq/μmol after 63 min of radiosynthesis including HPLC purification and formulation. CONCLUSION: The automated radiosynthesis provides high and reproducible yields suitable for routine clinical use. |
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Authors:
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Thomas Bourdier; Ivan Greguric; Peter Roselt; Tim Jackson; Jane Faragalla; Andrew Katsifis |
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Publication Detail:
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Type: Journal Article Date: 2011-03-03 |
Journal Detail:
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Title: Nuclear medicine and biology Volume: 38 ISSN: 1872-9614 ISO Abbreviation: Nucl. Med. Biol. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9304420 Medline TA: Nucl Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 645-51 Citation Subset: IM |
Copyright Information:
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Crown Copyright © 2011. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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LifeSciences, Australian Nuclear Science and Technology Organisation, Locked Bag 2001, Kirrawee DC NSW 2232, Sydney, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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