Document Detail


Fully automated one-pot radiosynthesis of O-(2-[(18)F]fluoroethyl)-l-tyrosine on the TracerLab FX(FN) module.
MedLine Citation:
PMID:  21718939     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
INTRODUCTION: An efficient fully automated method for the radiosynthesis of enantiomerically pure O-(2-[(18)F]fluoroethyl)-l-tyrosine ([(18)F]FET) using the GE TracerLab FX(FN) synthesis module via the O-(2-tosyloxyethyl)-N-trityl-l-tyrosine tert-butylester precursor has been developed.
METHODS: The radiolabelling of [(18)F]FET involved a classical [(18)F]fluoride nucleophilic substitution performed in acetonitrile using potassium carbonate and Kryptofix 222, followed by acid hydrolysis using 2N hydrochloric acid.
RESULTS: [(18)F]FET was produced in 35±5% (n=22) yield non-decay-corrected (55±5% decay-corrected) and with radiochemical and enantiomeric purity of >99% with a specific activity of >90 GBq/μmol after 63 min of radiosynthesis including HPLC purification and formulation.
CONCLUSION: The automated radiosynthesis provides high and reproducible yields suitable for routine clinical use.
Authors:
Thomas Bourdier; Ivan Greguric; Peter Roselt; Tim Jackson; Jane Faragalla; Andrew Katsifis
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Publication Detail:
Type:  Journal Article     Date:  2011-03-03
Journal Detail:
Title:  Nuclear medicine and biology     Volume:  38     ISSN:  1872-9614     ISO Abbreviation:  Nucl. Med. Biol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304420     Medline TA:  Nucl Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  645-51     Citation Subset:  IM    
Copyright Information:
Crown Copyright © 2011. Published by Elsevier Inc. All rights reserved.
Affiliation:
LifeSciences, Australian Nuclear Science and Technology Organisation, Locked Bag 2001, Kirrawee DC NSW 2232, Sydney, Australia.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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